In Pitt et al.'s "The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Attacks," the researchers seek to answer the question of whether or not spirinolactone has a definitive effect on reducing heart failure rates in patients. Aldosterone is identified as one of the most important components of heart failure; as a result, aldosterone-receptor blockers are considered to be a potential treatment or therapy for those with severe heart failure.
In order to test the efficacy of spironolactone on those with moderate heart conditions and heart failure, a study was performed in which 822 patients were given regular treatment ...