1. The molecule chosen for the analysis is Immunicillin -H. It is a transition state analogue for the enzyme purine nucleoside phosphorylase (PNP). Chemically Immunicillin -H is [(1S)-1-(9-deazahypozanthine-9yl)-1,4-dideoxy-1,4-imino-D-ribitol] (Kicska et al. 2001)
2. PNP is important for the degradation of nucleotides, especially deoxy guanosine. In the absence of this enzyme, deoxy guanosine accumulates and inhibits T cell function, causing T cell mediated immunosuppression. Inhibitors of PNP were found useful in treating T cell malignancies. Inhibiting PNP using transition state analogue, triggers apoptosis of T cells. Though Immunicillin-H inhibits stimulated malignant and nonmalignant T cells, ...
Transition Article Reviews Samples For Students
26 samples of this type
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HANDLING CHILDREN WITH SPECIAL NEEDS IN THE SOCIAL ENVIRONMENT
According to Rous, Myers and Stricklin (2007), transition has a significant effect on the growth and development of children with special needs. Transition is described as the movement from one environment to another. Transition takes place through out our human life, it can be a change of location from one town to another or one school to another and it can also be a stage in life like from childhood through the teenage years and subsequent youth phase and finally to adulthood. Children with special needs have to be helped and monitored through out these transitions through prior planning and constant monitoring ...
The article “When a New Manager Takes Charge” by John Gabbaro explores what happens when there is a change of leadership at the management levels of companies. Gabbaro’s article documents why some managers are successful with the transition while others flop. In general, he documents that most managers take a relatively longer period to adapt to the requirements of the new work environments. The article makes a case that managers experience play a critical role in the success in the process of transition using examples from American and European managers. Mangers with experience of working in different environments take a relatively shorter time to ...
Technology: IT in the medical field / Outsourcing in IT
Cedars-Sinai Doctors Cling to Pen and Paper
Computers are becoming an integral element in our daily lives, and the medical field is not an exception. This is because of their ability to store enormous amounts of data and fast information processing capabilities and intelligence (Bansal, 2004). Computers play an integral role in medical operations ranging from aiding complex medical operations to simple procedures such as file and record keeping. Ceci Connolly notes a typical case in Los Angeles whereby Cedar-Sinai doctors are clinging to the traditional pen and paper to undertake their daily operations at the hospital. The effectiveness of ...
Reading Reflection:
“It All Just Clicked: A longitudinal Perspective on Transitions within University”
READING REFLECTION: TRANSITION TO COLLEGE 2
Reading Reflection: “It All Just Clicked: A longitudinal Perspective on Transitions within University”
The article I am read is a longitudinal study from a scholarly journal. The researchers were interested in the transition of students in a university educationally, socially and psychologically. They state, “Much of this has concentrated on the first year of university study, and has focused on investigating students’ knowledge of, and engagement with, a new learning community” (Hazel et al. 2014). The aim of this study was to follow ...
NO
This is an interview between Miller and Stephen Mosher about the impacts of population growth in a given country. Miller asks a question while Mosher answers the questions asked. In the first question, Miller is asking Mosher the reason why the imminent population have not materialised and where the mistakes could have come from. However, Mosher says that the consequences of overpopulation in some instances from Malthus and Paul Ehrlich’s are deliberately exaggerated in attempt to frighten individuals into having not more than one or two children.
The second question Miller asked was if the projections about ...
Cerebral palsy (CP)
Issues a case manager should be aware of while providing assistance
Cerebral palsy (CP) is a movement disorder which affects children at the initial stages of life. The symptoms of this disorder encompass weak muscles, tremors, and lack of coordination. Babies who experience this condition cannot sit or walk. In some cases, these babies cannot crawl and have difficulties in hearing and vision. This paper explores two research articles. In the first article, Arnould et al. (2015) focused on the effect of brain lesions on the functioning of the hand among children with cerebral palsy. The authors observed that ...
Article Review
Article Review
Introduction
The article, “Managing the Transition to a Free Labor Society: American Interpretations of the British West Indies during the Civil War and Reconstruction” by Nichola Clayton is devoted to the analysis of written sources regarding the slavery abolition during the Civil War in America and American isles. The main idea of the article is shown in the summary: American reaction to the abolition, shift in views of the white population and the political parties of the USA, an attitude of the Republicans to the black population freedom and black farmers. Firstly, the author describes the Morant Bay rebellion ...
Research Article Summary
Mouchawrab et al (2011), published an article in the journal of IEEE on transaction software engineering which was entitled “Assessing, Comparing, and Combining State Machine-Based Testing and Structural Testing: A Series of Experiments”. The main focus of the article was on the cost effective way of testing state machine on fault detection which is model-based in comparison with structural testing. The study uses controlled experiments and review of the previous findings to reach its conclusion. Uniform modeling language UML is the main focus in the study as a method of testing. UML according to the study is the most effective ...
Summary of Article Macy & holder
Complainant,
V.
Eric Holder,
Attorney General,
(Bureau of Alcohol, Tobacco, Firearms and Explosives),
Agency.
Short Description of the Case
The complainant was denied employment by the Bureau of Alcohol, Tobacco, Firearms and Explosives in the Walnut Creek Lab despite having the required qualifications. She was interviewed by the director of Walnut Creek Lab. The director told her that she would be hired after the lab conducts some background checks. At this time, Macy (complainant) was presenting herself as a man. However, as the process of background check was going on, she started her transition from male to female. She called her prospective ...
Introduction
Child development involves continuous changes psychologically, biologically and emotionally from the time of infancy up to the end of adolescence. Growth and development are always used interchangeably, but it is important to note the difference in that growth involves the physical changes in child’s body shape, size, height, weight, arms, and legs length whereas development encompasses a continuous progression in complex knowledge. A child’s growth and development are always divided into four periods; infancy, preschool years, middle childhood years and adolescence.
The study in this article is about the need to belong theory which gives the relationship ...
The design and goals of management policies are primarily influenced by the fisheries and marine ecosystems health mental concepts. The Cognitive Maps: Cartography and Concepts for an Ecosystem-Based Fisheries Policy article, discusses how these mental concepts that are held by some individuals are fostered by the approach of Back to the Future (BTF) to the policy of fisheries (Tony & Nigel 1976). Such cognitive maps are normally obtained from local and traditional knowledge and the interplay of science. The approach of Back to the Future action employs all the sectors in remedial and positive and is meant to engage the ...
Abstract
The article “Divorce Trends and Patterns in the Western World: A socio-legal overview”, written by Tony Fahey, contains a profound overview of all the patterns and trends in divorce in the modern world in developed countries of the Western World. It regards the definition of the world “divorce” and its meaning, the causes and reasons of divorce, the legal process, and usual consequences thereof. Tony Fahey has made a deep investigation of marital breakdown in the modern society over half of a century. The author indicates that though the number of divorces has radically increased recently, the reasons of ...
Disasters
The article by Sabrina McCormick (2015) focuses on the role and responsibility of emergency managers in using social media for formal response in case of a disaster. The article also gives detailed insights about crowdsourcing for emergency managers in disaster preparedness as well as response and recovery in the US. Different emergency managers from across the country are usually scheduled for qualitative interviews on the Eastern seaboard. This is a new way of ensuring that the emergency managers are up-to-date with the current emergency management tools. Emergency management tools are in a state of transition in this current era; ...
Abstract
Cancer of the lungs is among the leading causes of cancer in the world. It has two forms; small cell lung cancer (SCLC), and non-small-cell lung cancer (NSCLC). NSCLC constitutes about 85% of cases of lung cancer. Epidermal growth factor receptor (EGFR) and its mutations are found to have an important role in this cancer. Therefore, EGFR tyrosine kinase inhibitors (TKIs) can work effectively against NSCLC. Gefitinib, which is a first generation TKI, and afatinib, which is a second-generation TKI, are effective as a first-line therapy for advanced NSCLC. Erlotinib is effective as a second-line therapy for advanced NSCLC. ...
The first reading on the “Less for Less Yet" is important because it articulates the idea of creativity in the architectural field. It argues that the modernist has been having the problem concerning the beliefs held about the architectural ideas and how these ideas are being perceived in the society. It is important because it helps to identify and consider architecture as an idea of being creative in the society. The article puts across that the architectural creativity is the chief gift to society, and thus, it is important for the people to understand its importance. As compared to ...
Article APA Citation: Sachs, J. D., & Warner, A. M. (1999). The big push, natural resource booms and growth. Journal of Development Economics, 59, 43-76. Retrieved February 13, 2016, from http://dx.doi.org/10.1016/S0014-2921 (01)00125-8
Research Problem Addressed
The paper addresses the question of whether or not natural resource booms act as economic catalysts that low income countries can rely upon to overcome the fixed costs that come with the industrialization process as suggested by the big push reasoning. The authors’ main objective is to ascertain whether natural resource specialization by a country is an important strategy that can spur economic development. In this paper ...
The British Journal of Community Justice Vol.12 (2):57-66 is an article that discusses how the Corrections Victoria in Australia. The article identified the risk factors that drive women into offending and develop an extraordinary response to the women offenders. The report emphasizes particularly on support and re-integration of these women into the community.Moreover, it looks at the factors that influence women’s self-efficacy, as well as their community integration. The document further outlines the development of The Better Pathway Strategy. The strategy was developed with the realization of the implications of women’s imprisonment as far reaching, with ...
Name_________________________________________________________ Date:___________
- What is the main point that you want someone to read this paper to understand?
I want to point out the brilliant capacity of decision making of Telemachus. His maturity is reflected through his decision making and his adaptability. That is what I want to highlight from Telemachus's character.
- Where did you focus particular efforts in this paper?
I focused on the deep study of each and every action and decision of Telemachus. I just want to focus on the immense maturity level of Telemachus while dealing each and every situation.
- What ...
Article Review-1
Summary
This article analyzes declining economic growth of China. Additionally, it tells about several forecasts that predict even stronger slowdown of China’s economic growth in future, and discusses possible reasons of this decline. According to the article, average economic growth rate of China from 1980 and until two years ago was equal to approximately 10%. However, during the third quarter of this year, Chinese economy grew by only 7.3% year-on-year. Several sources, including experts from the Harvard University and the IMF, assume that the growth rates will fall to 6.3% by 2020.
One possible explanation for ...
Dear Dr. Xu:
Henceforth is my reflection on how the course affected my knowledge in writing; hence, proving that the goals and objectives – the course outcomes - of English 131 are fulfilled in me. Taking the course has, indeed, improved my writing style by making me more conscious and aware of my mistakes in writing. In order to showcase this improvement, I would be using my four previous writings: Arabic Spring, Liminals: Rhetorical Analysis, the annotated bibliographies submitted on 10 May 2014, and Analyzing Star Trek.
One of the most important lessons that I have learned from taking English 131 is ...
Is Apple Company any better after Steve Jobs Death?
Succession in Apple Company remained a tussle among the interested potential CEOs after the death of Steve Jobs death in 2011 (Chen). The employees of the company were worried and felt hopeless as they thought everything in Apple will change including the nature of the working environment and working conditions. There was a need for a more practical CEO who will streamline everything in Apple to raise its performance. While everyone though that Apple Company was on its ways to the grave with Steve Jobs, things turned out to be a surprise. Tim Cook took up the position and began to make everything ...
Every country in the world has undergone a gradual metamorphosis to arrive at their current status. China is not an exception. In the past millenniums, several dynasties ruled China and introduced distinct social-political changes, which had interesting succession dramas. These social and political struggles had two main competing interests; the quest for absolute power by the rulers and the people’s quest for affluence and equality. The Kangxi’s valedictory edict of 1717 provides a glimpse of this struggle. He lists some of his accomplishments in public service including sound financial policies that he initiated. Kangxi ruled as the emperor of ...
Introduction
Rite of passage refers to the occasion or an event that classifies an individual to have transition from on stage of life to another. This activity encompasses Clitoridectomy, rite, Circumcision, and infibulations. It is valued and treasure within the community. It normally commemorates or rather celebrated through performance of fork dances and songs to entice the entire event. It exists in between the current or present time and the standing reality. The rites of passage classified into different distinct forms namely territorial passage whereby a person is required to go by certain set formalities (Kasomo, 2010). The other type of ...
Analysis of an IEP: Opportunities Offered to Children with Disability
Article review
An IEP is an Individualized Educational Program that assists students with special needs plan a holistic program in their local public school district. The program aims to meet the child’s unique needs as well as keep them at par with their peers. The purpose of an IEP is to guarantee that children with disabilities access free public education that focuses on special segments and services that prepares them for further education, future employment, and independence.
Statements presenting the child s academic achievements
- How the disability affects the child from ordinary curriculum activity
Measurable child’s goals in an annual basis
- Childs ...
A Reflection by
Undeniably, with the advancement of technology, changing trends and consumer behavior, marketing is become one of the complex field. For many years, marketers have been in continuous adjustment to an era of profound customer engagement. Competitions are tremendously increasing due to unavoidable changes; hence, many organization are becoming more committed on customers engagement and working towards redefining marketing organization. In the past, marketing was only the work of marketer, but in this era, marketing has become an affair of all the people in the organization. The authors are informing the audience on the how marketing should be the activity ...