“Aboriginal” has since time immemorial been used to describe the indigenous inhabitants of places that were discovered and colonized by European nations. However, the word has of late found widespread use of the term aboriginal in the description of the Australian populace. Before the spread of western civilization most aboriginal languages were entirely spoken languages which did not have any writing system. Before the spread of western civilization, recording of information on written material was not common. This explains why most written aboriginal languages lack voice and identity. However non –aboriginal writers have made large strides in the transcription ...
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Hepatocellular carcinomas (HCC) exhibit genetic heterogeneity. Most of the HCC tumors are associated with activation of insulin/IGF-1/IRS-1/Ras/Raf/MAPK/Erk and a WNT/Frizzled receptors/β catenin signaling cascade which provides targets for therapy. All the pathways are mediated by genetic mutations and signaling compounds and the loss of regulatory proteins also contributes for tumor generation. Two signaling pathways are involved in the carcinogenesis which includes insulin/IGF 1/IRS 1/MAPK and Wnt/FZD/β catenin pathways.
The insulin/IGF-1/IRS-1/MAPK cascade plays a crucial role in regulating regeneration of liver and embryonic development. The constitutive activation of these cascades which is due to IRS 1 over expression leads to HCC ...