Mechanisms by which Incompatible Red Cells may be Cleared from Circulation
Introduction
One of the leading causes of transfusion-associated mortality is related to haemolytic transfusion reactions.1 Many factors that account for haemolytic transfusion, and complement activation is the most widely studied and documented feature linked with such reactions and fatalities, and many researchers have focused on the role of complement initiation, activation and regulation with respect to these reactions. Others have focused on the underlying strategies involved in mitigating the complement modulation, in the event of an incompatible red blood cell transfusion.1 Many reports have stated that incompatible red blood cell (RBC) transfusions are the leading cause of death in ...