The Ellen Roche case is a case wherein a healthy volunteer participated in a National Institutes of Health funded research on the natural defenses of healthy individuals against asthma. The purpose of the study is to “gain a better understanding of the pathophysiology of asthma, specifically the mechanism of airway hyperresponsiveness”. Under the experiment Roche and the other subjects are required to inhale hexamethonium, a ganglionic blocker. The subjects will be paid $365 for participating in the experiment. After almost a month of participating in the research, Roche died due to progressive hypotension and multi-organ failure, which was attributed to her inhalation of hexamethonium.
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