Literature Review Plan
Introduction
This section begins with the definition and a brief introduction of microRNA, its biogenesis and mode of action, how to identify miRNA targets, and the various functions of miRNA. The definition of tumorigenesis is also presented here. The section then concludes with a brief description of the topic and the importance of the topic.
The main theme
The main theme here is the role of miRNA in tumorigenesis. This section begins with a general overview of miRNA and cancer. It highlights the families of miRNAs with tumour suppressing activity such as MiR-15a and miR-16-1, and the Let-7 family. Also considered are the families of miRNAs with oncogenic potential such as MiR-372 and miR-373, MiR-17-92, MiR-21, and MiR-155. The section then concludes with a highlight of the different uses of miRNAs in clinic.
Research findings from similar studies
Highlighted herein are the various studies conducted on the role of miRNA in tumorigenesis and the findings of these studies. These studies include: the Genetic and epigenetic association studies and the role of miRNA biogenesis gene exportin-5 (XPO5) in breast tumorigenesis; the studies by Zhang et al. which reveals that miRNAs exhibit high frequency genomic alterations in human cancer; the studies by El-Murr et al. which shows that miRNA genes constitute new targets for microsatellite instability in colorectal cancer; the studies by Kota et al. which reveals that therapeutic miRNA delivery suppresses tumorigenesis in a murine liver cancer model; and the studies by Li Ma et al. which investigates tumour invasion and the role of microRNA-10b in breast cancer.
Conclusion
Presented here is a summary of the main findings from the above sections. It narrows down to the role of miRNA in tumorigenesis as found in these literature sources.
