The present essay describes the seminar on 5HT receptors and Hippocampus Stem cells. Mood and anxiety both are disorders related to cognitive behavior, and they have the similar genetic origin as well as treatment strategies. The research has exhibited that similar neural serotonin receptors are involved in pathological condition of mood and anxiety. Among all cognitive disorders, 10% are related to mood while 15-20% are associated with anxiety, showing mutual comorbidity of 30-60%. The lecturer talked about the Stem cells and neurogenesis in brain citing a quote “In the adult centers, the nerve paths are something fixed, ended, and immutable. Everything may die, nothing may be regenerated. It is for the science of the future to change, if possible, this harsh decree.” (Colucci-D’Amato, Bonavita, and Di Porzio 266-270). The main focus of the seminar has been the Stem cells in brain and characteristics of neurogenesis which is conserved across species including in rodents, monkeys, and humans. The latest approach to Hippocampal Stem cells and fast neurogenesis in these cells has opened novel directions for the treatment of neural disorders. The Hippocampal SCs can regenerate at a rate of 3000 new cells each day, out of which 80% die within 30 days while 20% survive according to the surrounding conditions. These survivors become mature neurons and develop into axons and dendrites. These newly developed neurons are capable of hippocampal functions like memory and learning. The main two questions discussed in the seminar are: Why neurogenesis only occur in adult hippocampus SCs and how it can influence the cognition and mood? Lecturer discussed pattern separation and pattern completion including dendate gyrus. The imaging of hippocampus in a still mouse is discussed with activity code signifying the Post-traumatic stress disorder.
Overall, the seminar has summarized the generalization and pattern separation approach in patients with cognitive abnormalities such as depression, anxiety and age-related memory problems. The lecturer concluded that the clinical trials based interventions grounded on this approach will help in enhancing neurogenesis targeting the patient with extreme generalization. It will provide valuable insights into the field of Neuroscience.
Works Cited
Colucci-D’Amato, L., V. Bonavita, and U. Di Porzio. "The end of te central dogma of
neurobiology: stem cells and neurogenesis in adult CNS."Neurological sciences 27.4
(2006): 266-270.
