Process Controls
An efficient compression method comprises of several control processes including machine operation, powder flow, and machine set up. For the tablet compression machine to operate at maximum performance, the machine should be assembled at appropriate tolerances, and the compression tooling should be matched for length. The speeds of powder flow should be coordinated to maintain uniformity. The granulation flow may be controlled by an automated system or by gravity depending on the complexity of the system (Gerhardt). The powder blend should be used to determine the compression machine’s parameters yield the appropriate attributes.
Parameters Monitored
The time used to complete a batch of tablets is monitored to provide insight into the efficiency of the process. At optimal efficiency, the machine should be able to complete processing a batch of tablets at maximum speed without any interruptions (Gerhardt). The target force is also monitored to ensure that it does not go below or above the prescribed levels. Fluctuations in the target force will affect the desired tablet weight, hardness or thickness. Finally, after the compression process is done, the tablet weight is checked. This is a simple process since the machine automatically weighs individual tablets and rejects the once that are out of specification.
Adjustments to Improve Quality
The parameters that need to be adjusted to produce high-quality tablets include compression force and turret speed. Increasing the main compression force in challenging lots achieves sufficient tablet strength. However, care must be taken not to exceed the powder blend bonding level force since this will diminish tablet hardness. Formation of stronger tablet bonds can be achieved by reducing turret speeds to allow for longer dwell times at maximum compression force. Exerting partial force before the final tablet compression can also increase tablet bonds.
Works cited
Gerhardt, Armin. H. “Fundamentals of Tablet Compression.” Journal of GXP Compliance 14.1 (2013): 70–79. Web. 2 Apr. 2016.
