Among the many problems and challenges that human beings face in the twenty-first century is the disorders related to the central nervous system. Some of these disorders include traumatic brain injury (TBI) and cerebral infarct. As such, doctors have identified the necessary mechanisms to address these issues that put human life to danger. One of the mechanisms that have been employed is that of identifying the prospective donor cells. Some of these donor cells may include neural stem cells, embryonic stem cells and the bone marrow stromal cells (BMSCs). This is very important in that the life of a human being can be extended in case of a disorder.
The reference that the author gave is very essential in establishing whether the transplantation therapy can yield positive results. Through it, the author’s intention is to demonstrate, through practical experience, that BMSCs is the most essential donor cells. This is because these cells can be collected from the patients themselves, without any negative effect or any other immunologic problem. Further, the reference demonstrates that, through BMSCs, tumorigenic effects are not activated. The author performs experiments aimed at understanding the biological positions of such transplantations, by using rodents as specimen.
In this reference, the author used the technology of intra-arterial delivery concerned with the BMSCs. Essentially; this technology seeks to promote the TBI recovery in rats. Through this general knowledge that is proven, then conclusions can be made that the same can successfully be applied to humans. This technology is essential in that it provides another option to the treatment of the victims to such disorders (Kuroda).
After the experimental transplantation, positive and encouraging results were achieved. Within a period of three hours, the BMSCs that had been transplanted migrated to the injured central nervous system from the cerebral capillary bed. All this happened without any systematic circulation. As such, the conclusion from this reference is that this BMSC transplantation promotes the functional recovery (Kuroda). BMSC transplantation as shown in the reference is a valuable option to any injured central nervous system tissue problem. Essentially, this is because of the manner in which it affects the TBI outcomes. In another study conducted by Kuroda S, rt.al, on ‘Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders’, shows the application of bone marrow stromal cells offers hope of a cure in individuals with nervous system disorders. This study therefore, increases the body of knowledge in this field for the advancement of nervous system disorders treatment.
References:
Kuroda, S., Kuge, Y., Tamaki, N., & Iwasaki, Y. (0). Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders: Perspectives for Translational Research and Clinical Application. doi:10.1007/978-4-431-98074-2_13
