Cadburyoma: A chocoholoma syndrome
Maria suffers from a rare syndrome termed Cadburyoma. It is a disease caused by consumtion of cadburo disease. It initially affects the cardiovascular and gastrointestinal system of the body. Further on when the disease reaches its peak level, neuronal problems arise. Cadburyoma is seen in both males and females and is more prevalent in urban lifestyle.
History
It was first coined by a Lyndon F, a scientist working in the Ohio state university. He observed that patients with Cadburyoma had various cardiovascular problems. He noticed that these patients suffered from varied ailments in the cardiovascular system which included: arrhythmia, angina pectoris, hematoma, valvulitis and thrombophlebitis. Aoudumbari Desai was the first patient to be diagnosed with cadburyoma. She later died at the age of 24 due to multiple complications.
Causes of cadburyoma
Main cause was found to be cadburo choclates. But further studies showed that some more chocolates also caused chocoholoma syndrome but in lower levels. Diet, exercise play an important role in the causation of the disease.
Symptoms and signs
As we know that cadburyoma affects multiple systems of the body, signs and symptoms are varied. In the cardiovascular system mainly mitral valve stenosis, intermittent claudication, cardiac tamponade, arrhythmia and angina pectoris were observed. These signs are most prominent but cannot provide full proof indications for this syndrome.
There are multiple indications observed in the gastrointestinal system. These include: hematomegaly, Murphy's Sign, Robsing's Sign, bowel sounds and abdominal distention. More complex signs include haemorrhoids, hematochezia, hematemesis, coffee-ground emesis, ascites, varices and ulcerative colitis. These indications are complex and immediate treatment is required. Doctors sometimes recommend surgery for severly damged tissues and organs.
In later stages there are severe problems in the nervous system. This is a much more complex and result is delayed treatment of the patient. Individuals often show signs of encephalitis, hydrocephalus, neuralgia, syncope, cerebral concussion, cerebral contusion and migraine headache.
Diagnosis of Caburyoma:
In the diagnosis, Doctors recommend to check both the cardiovascular and gastrointestinal system all together. For the cardiovascular system test includes: Venous Imaging, Arterial Imaging, Carotid Duplex Imaging, Echocardiogram, Neonatal Echocardiogram, Transesophageal Echocardiogram, Stress Echocardiogram, Dobutamine Stress Echocardiogram.
For gastrointestinal system test recommended by doctors and health care physicians include: Air contrast enema, Barium enema, Barium swallow (Esophagography), Cholangiography, Cholecystography, Faecal occult blood test, Liver biopsy, Gastro-oesophageal reflux, Oesophageal manometry, Oesophageal pH monitoring, PCR status and Hepatitis C transmission. These test are only provide the patients current health status and further diagnosis is recommended by the physician.
Treatment of chocohlic syndrome:
For cardiac problems angioplasty, artherectomy, endarterectomy, pericardiocentesis, valvuloplasty, aneurysmectomy are recommended depending on the extent of damage to the heart and peripheral region. On the other hand (percutaneous transluminal coronary angioplasty) PCTA, intracoronary thrombolytic therapy, embolectomy, (coronary artery bypass graft) CABG, aneurysmectomy and valvuloplasty are recommended.
For Gastrointestinal issues doctors recommend surgery. These include cholecystectomy, colostomy, ileostomy, ostomy, and paracentesis. However surgical procedure depend on the severity of the affected organ.
Epidemiology
No vaccines have been available for chocoholoma syndrome. It is due to the variance of disease statistics. Primarily only surgery of affected organs are recommended.Drugs to some extend are recommended but have not shown any improvement in the disease. The risk of the disease is more prevalent in cities since the amount of cadburo chocolate consumers are high.
Current Trends:
No vaccines are available till date. Researches are developing novel proteins to reduce the cause of the disease. Many doctors along with research scientists are in the main focus study bradycardia, cardiomegaly, cardiomyopathy, ischemia, endocarditis, phlebitis and pericarditis in patients with cadburyoma. In India at the K.E.M hospital located in Mumbai, scientist are in the phase 2 of clinical trials to study ataxia, aphasia, analgesia, bradykinesia, cephalalgia, paresthesia and sciatica in patients with chronic cadburyoma.
Statistical Data
Over 100 million people suffer from cadburoma. Both males and females have found to have contracted the disease. According to WHO statistics there are more female patients compared to males. In Asia the disease has increased ten-fold owing to increase in urban lifestyle and consumption of chocolates. In the US, more than 10 million people suffer from caburyoma. The basic reason being excessive consumption to chocolates and inadequate exercise and sedentary lifestyle. In 2010, there were more than 2 million people who suffered from chronic cadburyoma. The risk of disease is more prevalent in men above age 30 and women above age 40. More than 90% of cases lead to death in chronic cadburyoma. Pediatric studies have not shown any statistical significance. More than 70% of cadburyoma patients suffer from both cardiovascular and gastrointestinal disease.
Conclusion
Cadburoma is a fatal disease if not diagnosed at early stages. It can cause complex disorder in the nervous system which is quite fatal and may also lead to death. Many novel drugs are in the market for the treatment of the disease. Diagnosis of the syndrome is simple and can lead to immediate treatment. Chronic cadburoma is often fatal and requires a combination of various drugs. Novel drugs are being tested in clinincal trails for the betterment and quality of life with individuals with chocoholic syndrome.
Total Medical Terminology Words and Abbreviations: 55
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