Literature review
Pharmacogenomics according to Dr. Valle is the study of how genes can affect a person's response to drugs, and it involves the combination of pharmacology and genomics, that is, the study of genes and their functions. He, therefore, asserts that knowing the patient's status whether they carry the genetic variations can assist the prescribers to individualize the drug therapy to reduce the chances of adverse drug effects and increasing the drugs’ effectiveness. It combines the pharmaceutical sciences like biochemistry and the knowledge of DNA variations in the human genome (Johnson, 2013, pp. 835-838). The current studies deliberate on the field of pharmacogenomics and how the genes can encode the metabolic enzymes or structural proteins that can result in susceptibility to diseases.
Dr. Valle's interest entails understanding the aspects of the contribution of the genetic variation in human health and illnesses. His studies revolve around clinical, molecular, biomechanical, and therapeutic aspects of human genetic diseases. Drug discovery and the development around the genetic mutations has had impacts on medicines and genetic indications and more particularly, in the search for treatment of cancer (Johnson, 2013, pp. 839-843). The clinical implementation of pharmacogenomics has dramatically grown in the recent years, and the specialists are working towards identifying the related treatments. The clinical community, however, argues that there is no sufficient evidence for the testing of this pharmacogenetics.
Dr. David Valle explanation of pharmacogenomics and that of the research article tell more of how it is important to understand the discipline to reduce the adverse effects of drugs by affected individuals. It is evidence that there is the need to learn the discipline in the field of nursing so that the carrier individuals can get drug prescription accordingly (News & Views, 2013, p.1543). However, it is said that there is no evidence for clinical testing so far.
References
Johnson, J. A. (2013). Pharmacogenetics in clinical practice: how far have we come and where are we going? Pharmacogenomics, 14(7), 835-843. doi:10.2217/pgs.13.52
News & Views Pharmacogenomics. (2013). Pharmacogenomics, 14(13), 1541-1543. doi:10.2217/pgs.13.174
