Article 1
This article is basically a review of microRNAs and their role in cancer. It briefly introduces miRNAs and focuses on miRNA biogenesis and mode of action. It then looks at the functions of miRNAs with respect to their involvement in cancer, and their potential use in clinics.
My literature review topic is about the role of miRNAs in tumorigenesis while this article is about the role of microRNAs in cancer. These two topics are technically the same. My review topic therefore shares a lot in common with this article, such as the miRNA biogenesis and mode of action and the functions of miRNAs in cancer. The terms I’m unfamiliar with include oncomirs, siRNAs, adenocarcinoma, glioblastoma, and c-Myc.
The potential search terms (key words) include microRNAs, carcinogenesis, oncogenes, and tumorigenesis. I want to find out more about how miRNAs may be used for cancer prevention.
References to this article:
Lagos-Quintana M, Rauhut R, Meyer J, et al. (2003). New microRNAs from mouse and human. Rna 9(2):175–9. This article is available online at http://rnajournal.cshlp.org/content/9/2/175.long
Bertone P, Stolc V, Royce TE, et al. (2005). Global identification of human transcribed sequences with genome tiling arrays. Science, 306(5705):2242–6.
Carninci P, Kasukawa T, Katayama S, et al. (2005). The transcriptional landscape of the mammalian genome. Science, 09(5740):1559–63.
Frith MC, Pheasant M, & Mattick JS. (2005). The amazing complexity of the human transcriptome. European Journal of Human Genetics, 13(8):894–7.
Okazaki Y, Furuno M, Kasukawa T, et al. (2002). Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature, 420(6915):563–73.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature Genetics, 36(1):40–5.
Note: This article has 198 references and only the first five are included herein and formatted according to APA.
Article 2
Ma L, Teruya-Feldstein J, & Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature, 449(11): 682-688.
This is a research article about tumour invasion and metastasis and it demonstrates the role of microRNA-10b in breast cancer. This is done using a combination of mouse and human cells. The findings from this research suggest the workings of an undescribed regulatory pathway where expression of a specific microRNA is induced. The microRNA suppresses its direct target and activates another pro-metastatic gene, which leads to tumour cell invasion and metastasis.
While my literature review topic is about the role of miRNAs in tumorigenesis, this article is about tumour invasion and metastasis initiated by microRNA-10b in breast cancer. My review topic is general and broad while this article is specifically about microRNA-10b. It suggests the role of microRNA-10b in breast cancer, thus directly relates to my review topic.
The terms I’m unfamiliar with include haematopoietic differentiation, epithelial–mesenchymal transitions (EMTs), HOXD10 mRNA, and Oligonucleotide transfection.
The key words are Metastasis, microRNA-10b, and breast carcinomas.
I want to find out more about how to identify the entire complement of miRNAs and their mRNA targets to clearly explain the contributions of these miRNAs to high-grade malignancy.
References to this article:
Iorio, M. V. et al. (2005). MicroRNA gene expression deregulation in human breast cancer. American Association for Cancer Research, 65, 7065–7070.
This article is available online at http://cancerres.aacrjournals.org/content/65/16/7065.full.pdf
Some of the references for this article include:
Batlle, E. et al. (2000). The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biol. 2, 84–89.
Bolos, V. et al. (2003). The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J. Cell Sci. 116, 499–511.
Cano, A. et al. (2000). The transcription factor snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol. 2, 76–83.
Comijn, J. et al. (2001). The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 7, 1267–1278.
Fidler, I. J. (2003). The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nature Reviews Cancer 3, 453–458 (2003).
Note: This article has 47 references and only the first five are included herein and formatted according to APA.
