Dose Reports Samples For Students

Article 1: Radiation Associated Brainstem Injury

The tolerance of the central nervous system (CNS) to radiation treatment is significant to patient under treatment for metastatic or primary diseases associated with neck, brain and head. In most cases, brainstem injury is graded by most widespread toxicity criterion of the Cancer Therapy Evaluation Program based on symptoms. The first grade is considered mild, the second grade is moderate and without the capacity to interfere with daily living activities. The third grade presents extreme interference with the activities of daily living while the fourth grade is life threatening. The manifestation of severe radiation therapy induced central nervous system ...

Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.

This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...

The Metabolism of (PABA) Para-Amino benzoic Acid

Introduction
PABA or Para amino benzoic acid is a non proteinous amino acid that occurs naturally. The molecular formula of para- amino benzoic acid is C7H7 NO2; the structure of PABA consists of benzene rings substituted with a carboxyl and an amino group. PABA is a white crystalline molecule that is only sparingly soluble in water. PABA is a very essential nutrient for bacteria PABA functions as an intermediate in the synthesis of folic acid in bacteria
The deficiency of PABA does not cause any deficiency diseases in man. Some bacteria in the intestinal tract can synthesise PABA from chorismate. Humans ...

1. Which of the following is an antidote for benzodiazepine overdose or toxicity?a. Buspirone (BuSpar)b. Hydroxyzine (Visteril)c. Flumazenil (Romazicon)d. Naloxone (Narcan)There is one other drug overdose antidote in the above list. Name the drug and its mechanism of action. Flumazenil (Romazicon®) is another drug given to reverse the depressant effects of benzodiazepine and thus useful for overdose treatment. It acts as a competitive antagonist of benzodiazepines, having high affinity to GABAA receptors, which is the BZD binding site. This allows it to specifically target benzodiazepine and drugs with similar MOA such as zolpidem, but not other ...

Technical Fact Sheet

CHEMICAL CLASS/TYPE
Morphine is an opiate alkaloid, which are a group of chemical compounds with analgesic (pain-relieving) and narcotic (sleep-inducing) properties. Similar compounds in its class include buprenorphine, and the synthetic opioid heroine.
It is found naturally in the environment in the sap of the opium poppy plant, Papaver sominferum (National Center for Biotechnology Information, 2012).
These compounds exert their actions on the body through the opioid receptors, which are found on many different tissues. Morphine has widespread effects in the body, of which the most prominent are on the central nervous system and on smooth muscle ( ...

LAB REPORT: ELISA PRACTICAL

Snakebites are clinically challenging because of the diversity of species and varying concentrations which impact the severity of envenoming on the victim. Other clinical problems can arise due to (a) unpredictable dose quality, (b) determination of appropriate dose, (c) local site of the snakebite and (d) route of injection (Warrell, 1996). The time that has elapsed from the snakebite event until presentation at hospital is the most important mortality-determining factor. The health status of the human victim is important for how local effects, systemic coagulopathy, and/or neurotoxicity exhibit (Warrell, 1996).

Intravenous doses are prepared from IgG of a single or multi- venom ...

Abstract

Rose hip (Rosa Canina), often cultivated for its fruits, are orange-red oval berries, which seeds (including shells) are used in supporting the treatment of bladder infection, diarrhea, diabetes, and related conditions often in the form of a 3-g powdered seeds capsule. Its seed oil contains ascorbic acid, carotenoids, polyphenols, and GOPO, which reduces inflammation and pain, and lowers inflammatory markers. Extraction methods used include solvent extraction, supercritical fluid extraction, and subcritical fluid extraction. Licensed rose hip supplement products include Hyben Vital and LitoZin/i-flex. Hyben Vital dosage is twice daily for 3 to 4 months to reduce osteoarthritic pain and ...

Based on the initial symptoms, the patient most likely suffers from hypothyroidism or low thyroid hormone disorder. Further clinical tests and an examination of the family’s medical history reveals that the particular disorder could be Hashimoto’s disease; also called Hashimoto thyroiditis. Hashimoto thyroiditis is classified as an autoimmune disease. In autoimmune disease, one's immune system attacks the body’s tissue specifically the thyroid gland (Skugor & Wilder, 2006, p.2). By attacking the thyroid gland, the disease reduces the gland’s ability to produce thyroid hormones of substantial quantity. This condition leads to hypothyroidism. Thyroid hormone deficiency presents with ...

Textile designer "Toshiko Horiuchi

<Lecturer’s Name and Course Number>

Introduction

Toshiko Horiuchi is one of the leading fiber artists of Japan who makes use of knitting and crochet. She is well known for her large, interactive environments made out of crochet and textile (Hosmer, 2012). It is an experience to be in those imaginative and vibrant explorations of color and form that create a thrilling play environments for the children. She studied fine art and weaving in Tokyo at the Tama Art University and later at the Cranbrook Academy of Art in Michigan (Hemmings, 2014). If one comes across a very cool ...

Report on Vinyl Chloride

Report on Vinyl Chloride
The case involves a man who went into a polymerization tanks measuring 8 feet in high and 5 feet wide. The man went into the tank alone at night, and there was no light in the pit. After 20 minutes, the man did not return, and somebody went to check him. The man was found lying in the pit. The person who was looking for the man climbed in order to get the man out, but the person was overwhelmed by the gas. The person immediately shut the open valve feeling dizzy. The person dragged himself ...

- Abstract
Cardiovascular diseases such as heart failure are some of the leading causes of mortality and morbidity with Australia being one of the country’s most greatly affected (McLean, Esclick & Coats, 2006). An area of interest in the pathology of heart failure is the significance that polymorphisms of adrenergic receptor genes have on the outcomes of patients with heart failure. Single-nucleotide polymorphisms or SNPs that occur in the genes that encode for adrenergic receptors are known to have various physiological and functional consequences. Specifically, the β1-adrenergic receptors have a crucial role in the regulation of heart rate and ...

Report on Vyvanse (lisdexamfetamine dimesylate)

According to Pubmed, (2011), the use of the drug Vyvanse is used to treat ADHD (Attention Deficit Hyperactivity Disorder). ADHD is a condition in which the patient is hyperactive, impulsive, or inattentive. This drug works to release amphetamines which are stimulants that have a soothing and calming effect on the patient (Pubmed 2011).
ADHD is a common childhood behavioral disorder that affects approximately 3-5% of school going children. While the cause of ADHD is unclear, it is sometimes noted in family members indicating a possible genetic origin (Pubmed 2011).

Review of Package Insert

The package insert of this drug is very detailed and gives comprehensive information ...

Abstract

The term "opiate" combines substance extracted from opium, the most important of which is morphine, codeine, papaverine, which is widely used as medicines and paramorphine - used mainly in medical industry to produce medications, as well as synthesized derivatives of morphine, which belong to the semi-synthetic opiates and among which the most famous for their narcotic properties is heroin. Substances, differ in structure from the structure of morphine but operating on a similar mechanism (through opioid receptors), are belonged to the opioids (Kuehn, 2007).
A rich lexicon of slang in relation to opiates (especially heroin) reflects not only the " ...

Introduction

All organisms including human beings are exposed to a myriad of toxins from within the environment .The food we eat, the water we drink and the air we breathe, soaps ,cosmetics and other chemicals used in our daily lives contain toxins. Almost everything within the environment if taken in sufficient amounts can turn out to be poisonous or harmful .Therefore; there is a need to apply quick and cheap methods of testing and to determine the amounts of toxins in substances. Toxicity presents a complex variation between individuals. An amount that can harm one individual may not harm the other person.
...

Introduction

The simulated experiment of the practical is about the addition of agonists and antagonists on a guinea pig ileum and observing the effect of these agonists and antagonists on the ileum. This experiment is carried out with an aim to determine the effects of different concentrations of agonists and antagonists on the ileum of a guinea pig. In this experiment the type of data that are to be collected include the traces of acetycholine in the guinea pig ileum on addition of different concentrations of matropine. The expected values of the experiment are that the contraction of the ileum to change ...

A better understanding of memory consolidation and contributory factors is necessary to determine how it applies to the field of education. The following is a review of three studies on memory consolidation in the performance of different motor skill tasks by different population groups using a variety of independent variables.

Study #1

Purpose of the Study
Terpening et al. (2012) aimed to investigate the relationship between certain characteristics of sleep and the ability to learn and correctly perform a motor skill, namely sequential finger-tapping. The researchers recognized the limited number of studies done thus far on the neurological disturbances that occur in patients ...

Introduction

Primary health care (PHC) is considered the pillar of health care systems because it aims to reduce health-related inequities and enhance access to health care. It is regarded as essential, universally accessible and affordable health care founded on interventions that have been scientifically proven (UNICEF 2008). PHC is comprised of the following elements: “health education, adequate nutrition, maternal and child health care, basic sanitation and safe water, control of major infectious diseases through immunization, prevention and control of locally endemic diseases, treatment of common diseases and injuries, and the provision of essential drugs” (UNICEF 2008).
However, decades after ...

The play, Wit, by Margaret Edson, tells the story of Professor Vivian Bearing. The play opens with a monologue by Vivian in which she shares with the audience that she has been diagnosed with stage four ovarian cancer, and that she will be dead by the end of the play. The following scenes explore Vivian’s past as well as her present. She offers commentary throughout the play, as she becomes the narrator of her own life, and ultimately, her own death. Through this commentary, we as an audience are allowed to witness Vivian’s personality. We learn what she ...

Wd Count: 1472

Introduction

Dextropropoxyphene is a drug used as a painkiller. The mild opioid can alleviate long-term or short-term pains. Dextropropoxyphene is an opioid that is a morphine-related drug. It acts on the neural system in the spine and the brain and hence relieves pain. The drug has been available for use by blending it with other drugs or on its own. In the recent past, use of the drug has been rejected by several countries, among them Australia, because of safety reasons. In Australia, the drug has been recently in March 2012 following discoveries that Dextropropoxyphene can cause changes in the electrical activity ...

Chemistry

Trizivir:
Ingredients: 3 synthetic nucleoside analogues with inhibitory activity against HIV-1. “A recently approved antiretroviral looks like a nucleoside reverse transcriptase inhibitor (NRTI), but it acts like a protease inhibitor” (Portyansky 1999).

Active Ingredients:

1. abacavir sulfate, 300 mg (aka Ziagen™)
2. lamivudine, 150 mg (aka EIVIR™ or 3TC™)
3. zidovudine, 300 mg (aka RETROVIR™ or azidothymidine, ZDV or AZT because of Azide functional group).

Additives:

1. titanium dioxide
2. hypromellose
3. yellow iron oxide

Coating on Tablets

Is FD&C Blue No. 2, hypromellose, polyethylene glycol, titanium dioxide and
yellow iron oxide

Inactive Ingredients:
1. sodium starch glycolate
...