Receptor Reports Samples For Students

- Abstract
Cardiovascular diseases such as heart failure are some of the leading causes of mortality and morbidity with Australia being one of the country’s most greatly affected (McLean, Esclick & Coats, 2006). An area of interest in the pathology of heart failure is the significance that polymorphisms of adrenergic receptor genes have on the outcomes of patients with heart failure. Single-nucleotide polymorphisms or SNPs that occur in the genes that encode for adrenergic receptors are known to have various physiological and functional consequences. Specifically, the β1-adrenergic receptors have a crucial role in the regulation of heart rate and ...

Introduction

The Extracellular signal-regulated kinases (ERK) pathway is one of the most important signal transduction systems in a cell. This pathway regulates a lot of the fundamental processes of the cell including cell growth control and also cell death. The ERK pathway’s basic structure includes a couple of phosphorylations. The pathway provides a channel for the passing of signals from receptor that is located on the cell surface to the DNA inside the cell nucleus.
The signal transduction process through the ERK pathway is a complex process. Initially, the signaling molecule, that is, the epidermal growth factor (EGF) usually binds itself to a receptor ...

Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.

This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...

Introduction

The simulated experiment of the practical is about the addition of agonists and antagonists on a guinea pig ileum and observing the effect of these agonists and antagonists on the ileum. This experiment is carried out with an aim to determine the effects of different concentrations of agonists and antagonists on the ileum of a guinea pig. In this experiment the type of data that are to be collected include the traces of acetycholine in the guinea pig ileum on addition of different concentrations of matropine. The expected values of the experiment are that the contraction of the ileum to change ...

An investigation into the cholinergic receptor control of gastric muscle activity through the action of neurotransmitters

Introduction
Different types of neurotransmitters have different effects on the activity of the smooth muscle. Neurotransmitters exert their effects on smooth muscle through binding to different types of neurotransmitter receptors present in smooth muscles. Smooth muscles are involuntary muscles in the body that do not have the ability of controlling their own movements. Smooth muscles are unstriated because they lack the visible cross striations available in other types of muscles like the skeletal muscles (KCUMB, 2012).
Smooth muscles are small in diameter 2-10mm. The muscle fibers that make the single unit muscle are complied together into sheets. ...

Background

Based from the interview and observation, the two most common diseases occurring in both sides of the family are: (1) diabetes, specifically NIDDM, and (2) heart disease, specifically atherosclerosis. These diseases are commonly known as lifestyle diseases mainly because of their non-curable characteristic.
It was found out that diabetes, in the family, might skip a generation because one of our grandparents had it, but none of their children or our parents was able to acquire diabetes. However, this is still only a theory and is not yet conclusive as we are yet to establish the prevalence among our (second) generation. ...

Congestive heart failure

Congestive heart failure is by caused by amongst other reasons heart failure occurring due to either or both systolic and diastolic ventricular dysfunction. The use of the term “congestive heart failure” is used to imply that the patient in question is having some form of fluid overload. Congestive heart failure is a major cause of morbidity and mortality accounting for a significant proportion of hospitalizations. Of further note is that its incidence increases with advancing age (Tansley, 2010, p.1396). Although the presenting signs and symptoms of CHF have remained the same over time, great advances have been made in terms of ...

1. Overview

The peptide hormones are proteinous in nature and may have 3 to 200 amino acids residues. This class of hormones includes all the hormones of the hypothalamus and pituitary, as well as insulin and glucagon of pancreas. Peptide hormones are named based on their endocrine activity rather than their chemical structure; for example, growth hormone is thus named because one of its effects is to stimulate growth. The structure of a particular peptide hormone can vary among different species, with some homology between close relatives. Some small peptides are identical; for example, GnRH is identical among mammals but different in ...

Based on the initial symptoms, the patient most likely suffers from hypothyroidism or low thyroid hormone disorder. Further clinical tests and an examination of the family’s medical history reveals that the particular disorder could be Hashimoto’s disease; also called Hashimoto thyroiditis. Hashimoto thyroiditis is classified as an autoimmune disease. In autoimmune disease, one's immune system attacks the body’s tissue specifically the thyroid gland (Skugor & Wilder, 2006, p.2). By attacking the thyroid gland, the disease reduces the gland’s ability to produce thyroid hormones of substantial quantity. This condition leads to hypothyroidism. Thyroid hormone deficiency presents with ...

Introduction

The neurophysiology of nerve pulses in the cell were the subject of the online laboratory experiment in order to better understand neuron communication from inside a cell to the outside of a cell. One of the incredible characteristics of the nervous system is its capability to communicate due to the existence of neurons. Neurons show a measurable response to their environment by producing an electrical signal. We can smell due to olfactory sensory neurons that can directly react to perfume, food or anything with an odor; these odors are the sensory stimuli. The function of the receptor potential is to trigger an ...

Introduction

Mutation induces the formation mRNA strands that are formed later that they are converted into a native protein. Mutational causes the peptide formed develop a structure similar to a protein. Antimicrobial peptide formed after mutation depends on the chemical property. Mutation causes bacteria to increase in the peptide leading to low hemolytic function. Bacteria lead to anoplin to causing the shape of peptide to form a protein like shape that is spectroscopy.
Mutation causes the chain of the peptide to form a protein structure that later forms a tertiary that is the antigen molecule responsible for forming the body immune system. The chains amino ...

Introduction

Pain is an essential part of the body’s defense system which is perceived as an unpleasant feeling. Pain produces a quick warning to the central nervous system to start motor response as a minimization of harm. Lack of pain perception is dangerous can cause grave problems such as Auto-amputation, corneal scarring or self-mutilation. Researchers in the medical profession have distinguished between pain and what is known as nociception. Nociception occurs when signals get to the central nervous system as a result of the activation of nociceptors (Svokos & Goldstein, 2009). Nociceptors are special sensory receptors which relay information regarding tissue damage. Pain ...

Introduction

The studied muscles on which this report is based make part of the skeletal muscles group; they are connected to the bones by “tough cords of tissue” (NIH 2012) which are called the tendons and, as they contract, they pull these same tendons and the bones attached, causing movement. These movements are of voluntary nature, one being capable of controlling them as one wish to. The action of these muscles can be described as being initiated on the body’s standard or anatomical position and used for specific movements that one requires for a given activity. Some of these actions ...