Chemistry
Trizivir:
Ingredients: 3 synthetic nucleoside analogues with inhibitory activity against HIV-1. “A recently approved antiretroviral looks like a nucleoside reverse transcriptase inhibitor (NRTI), but it acts like a protease inhibitor” (Portyansky 1999).
Active Ingredients:
1. abacavir sulfate, 300 mg (aka Ziagen™)
2. lamivudine, 150 mg (aka EIVIR™ or 3TC™)
3. zidovudine, 300 mg (aka RETROVIR™ or azidothymidine, ZDV or AZT because of Azide functional group).
Additives:
1. titanium dioxide
2. hypromellose
3. yellow iron oxide
Coating on Tablets
Is FD&C Blue No. 2, hypromellose, polyethylene glycol, titanium dioxide and
yellow iron oxide
Inactive Ingredients:
1. sodium starch glycolate
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