Cancer is the abnormal proliferation and differentiation of cells in an abnormal tissue incongruent with the growth pattern of normal cells that persists even after the stimuli that evoked the change is withdrawn. The cell cycle check points at G1, G2 and at the end of metaphase that prevent transmission of genetically damaged DNA fail to occur. Transmission of faulty DNA results in either an abnormal rate of cell division and multiplication or abnormally constituted daughter cells.
The genes affected are the normal regulatory genes including growth promoting proto-oncogenes-normal genes that are prone to becoming cancerous on mutation ...
Cell Cycle Research Papers Samples For Students
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Cancers result from alterations in the genes that control cell proliferation, differentiation or apoptosis. Collins K et al (1997). Cells have a predictable way of proliferating, guided by internal machinery that controls such. Also, there are mechanisms to make sure that the process is error free. If there is any erring cell, there are mechanisms that make sure that the cell line is destroyed so that such defective cell is not perpetuated in the body system. All these processes are directed towards making sure that cancer cells do not develop. However, if there is any deviation from these check mechanisms, ...
Discussion
Periostin, an ECM protein, was named because of its expression in the periodontal ligament and periosteum of adult mice.30 PN is expressed in tissue growth and remodeling, as in cardiac and valvular development and disease, wound repair, tumor tissues, and inflammation.31-37 PN is also widely expressed in various atherosclerotic vascular lesions: it could be located in the intima, preatheroma regions, and the extracellular matrix of advanced lesions with calcification. PN variants are associated with extent of atherosclerosis in young persons, which suggest the importance of PN in the development of atherosclerosis in the arterial wall.38,39 This study used ...
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Cell Cycle
Introduction
Asymmetric cell division is a situation where a cell divides into parts of two cells that comprise two dissimilar cellular fates. For most part, the term applies and is usually used in referring to cells that are essentially diverse at the point of cytokinesis. Cytokinesis is the term used to describe how the cytoplasm and its organelles divide to form two separate cells. The daughter cell formed contains the same genetic material as the mother cell. This implies that individual daughter cell comprise a diverse physical makeup. This stands to convey the contrast surrounding extrinsically dissimilar cells where individual cell ...
- Introduction
Radiations such as - rays, UV rays, etc. have ionizing effects on tissues and have the ability kill cells and inactivate viruses. A detailed analysis of the survival of such cells and viruses are imperative in many fields, including radiation oncology, public health and environmental photobiology. However, the mathematical and statistical tools based on target theory in radiobiology are mentioned in literature (Alpen, 1988, Smith, 1989, Hall, 2000) and are wide in use in the analysis of experimental data involving biophysical mechanisms of the repair of radiation damage. This work demonstrates the use of probabilistic approaches ...
