Cancer is the abnormal proliferation and differentiation of cells in an abnormal tissue incongruent with the growth pattern of normal cells that persists even after the stimuli that evoked the change is withdrawn. The cell cycle check points at G1, G2 and at the end of metaphase that prevent transmission of genetically damaged DNA fail to occur. Transmission of faulty DNA results in either an abnormal rate of cell division and multiplication or abnormally constituted daughter cells.
The genes affected are the normal regulatory genes including growth promoting proto-oncogenes-normal genes that are prone to becoming cancerous on mutation ...
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Cancers result from alterations in the genes that control cell proliferation, differentiation or apoptosis. Collins K et al (1997). Cells have a predictable way of proliferating, guided by internal machinery that controls such. Also, there are mechanisms to make sure that the process is error free. If there is any erring cell, there are mechanisms that make sure that the cell line is destroyed so that such defective cell is not perpetuated in the body system. All these processes are directed towards making sure that cancer cells do not develop. However, if there is any deviation from these check mechanisms, ...
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