Aim: To identify the differential risk of peanut allergies among Chinese children in the U.S and China.
Introduction: Peanut allergy is a very common allergy among American children. Though the exact number of people affected by this condition is not known, millions of people in U.S suffer from peanut allergies, and the number is increasing. The reason for the high prevalence of this condition is not known. While in most children, the condition persists throughout life, in a few, it will subside and eventually disappears with growth and age. Unlike almonds, cashews and walnuts that grow on trees, peanuts ...
Immunology Research Proposals Samples For Students
3 samples of this type
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Specific Aims
Activation-induced cytidine deaminase (AID) encodes a DNA-editing deaminase, which is a group of the Cytidine Deaminase family (Bello). This protein is concerned in somatic gene conversion, hypermutation, and class-switch recombination of Ig (immunoglobulin genes). Activation-induced cytidine deaminase (AID) has been expressed in B cells at germinal center and starts the events, which lead to class switch recombination of immunoglobulin genes and somatic hypermutation. Additionally to this primary responsibility in immune diversification, deviant targeting of Activation-induced cytidine deaminase activity leads to translocations and point mutations of oncogenes linked with B-cell lymphoma. Lately, AID has been related in active DNA demethylation (Sariah).
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Introduction
Antigen Presentation
Antigen presentation plays a pivotal role in the immune system through which pathogenic antigens are processed and coupled along with major histocompatibility complex (MHC), and presented to T cells for their effector response. Macrophages, B cells and dendritic cells are the primary antigen presenting cells (APC’s). Intracellular antigens generated by viruses, or some cytoplasmic bacterial antigens are digested by the host cells and coupled with MHC Class I by Transporter associated with antigen Processing complex (TAP), which transports them to the cell surface and presents to CD8+ cytotoxic T cells (Germain, R 1994). These cells elicit a ...
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