The purpose of this paper is to review the etiology, pathophysiology, clinical manifestations, inheritance patterns, and recent advances in disease management of cystic fibrosis. Cystic fibrosis is a progressive and lethal disease resulting from an autosomal recessive gene (Singh, Rebordosa, Bernholz, & Sharma, 2015). The major problem associated with cystic fibrosis is the repeated lung infections that over time severely damage the lungs, scar and widen the passageways and limit the ability to breathe (Cystic Fibrosis Foundation, n.d.). As of 2013, there are an estimated 70,000 cystic fibrosis patients globally with 33,000 of them in the United States ( ...
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Literature review
Section 1: Background Context and rationale for research priorities Lens handling intensifies the incidence of lens contamination. When lens are aseptically removed from the eye, they still have a high probability of harboring microorganisms. During storage, the frequency of positive microbial bioburden remains high than 50%. The presence or movement of microorganisms from the lens to the ocular surface is a route factor for contact lenses related microbial keratitis and inflammation. There is need to priotise research in this area because the results of the studies help people to understand the factors concomitant to infectious and inflammatory complications. When ...
Infection in cancer patient with febrile neutropenia: epidemiology, microbiology and management
Abstract Febrile neutropenia (FN) is characterised by a decrease in neutrophils number to values below 500 cells/ mm3 and an occurrence of fever higher or similar to 38.3ºC. It commonly occurs in cancer patients as a result of chemotherapy regimens. Chemotherapy destroys carcinogenic cells but also attacks in many cases some normal cells including essential elements of the immune system. Fever is one of the characteristic symptoms of FN and is usually associated with the presence of an infection caused by various microorganisms. Bacteria, including Gram-positive isolates (currently dominating) and Gram-negative species (dominant in the 1970s), are usually ...