Some tricycle anti-depressants have been successfully used to lessen the problems associated with depression. This paper addresses information available about Clozapine (a tricyclic dibenzodiazepine), Protriptyline (a dibenzocycloheptene derivative), and Clomipramine (a dibenzazepine). Tricyclic antidepressants work by inhibiting the reuptake of norepinephrine and serotonin into nerve terminals. Clomipramine is prescribed to control obsessional behaviour (an antiobsessional drug); it is a very strong drug which must be used with care. The strong sedative properties of Clomipramine require careful observation of patients during the treatment. It was found the Clozapine is commonly taken by oral dosage to lessen effects of depression. Protriptyline which was marketed as Vivactil® has ...
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