Brittani Scott
Introduction Sickle-cell disease is an illness that is multisystem, linked to episodes of progressive damage of organ and acute illness, and is among the most common dangerous monogenic disorders in the world (Weatherall, Hofman, Rodgers, Ruffin, & Hrynkow, 2005). The sickle-shape erythrocytes were initially described in the year 1910 by Herrick (Herrick, 1910) and understanding has slowly increased from that time. Together with his colleagues, Pauling (1949) keyed out electrophoretic abnormalities in sickle HbS and made up the word molecular disease in the year 1949. The genetics, as well as biophysics of hemoglobin behind the disease, have been widely ...
