COPD is a medical condition that is characterized by alteration in lung parenchyma, bronchitis, emphysema and narrowing of the respiratory passages. It occurs as a consequence to chronic inflammation reaction involving the respiratory tract. The mucous secretion and fibrosis associated with chronic inflammation, can cause blockage and narrowing of the airway. Bronchitis refers to inflammation of the inner lining of the lung, while, emphysema is a clinical condition that occurs following the long term destruction of lung parenchyma. Bronchitis and emphysema are both characteristic features of COPD. Destruction of lung parenchyma causes loss of alveolar attachment and decreases the ...
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Describe the underlying pathology of COPD and the common pathological characteristics of the condition. Discuss the impact these pathological changes have on normal function, including how alveolar ventilation might be different in Mr Wenham compared to a normal individual. The hallmark pathological attributes of chronic obstructive pulmonary disease (COPD) are one, poorly reversible airflow obstruction and two, a progressive atypical inflammatory response within the lungs. The abnormal inflammatory response denotes the responses of the innate and adaptive immune systems to long-standing exposure to noxious gases and particles especially cigarette smoke. Notably, all cigarette smokers have some degree of inflammation ...