Essays on Carcinoma

Literature Review:

Factors and predictors of persistent lesion (positive hr-HPV DNA test or abnormal cytology) after treatment of high grade cervical intraepithelial Neoplasia with large loop excision of transformation zone (LLETZ) {Author Name} {Institution Affiliation}

Introduction

The Human Papillomavirus (HPV) infection is the primary factor that increases the risk of the cervical cancer development and cervical intraepithelial neoplasia (CIN) in the uterine cervix (Soderlund-Strand et al., 2014). Approximately 150 diverse types of HPV have been discovered, and most of them are carcinogenic. Persistent infections of high-risk HPV must lead to the development of high-grade cervical intraepithelial neoplasia (CIN 2 and 3), and ...

Questions and Answers

What term is used to describe the benign condition that may have caused the mass ? The term used to describe benign condition that might have caused the lump in this patient is called Benign Breast Disease, of BBD. This is an umbrella term that can be use to describe a wide “spectrum of noncancerous changes in the breast” (McCance & Huether, 2014). The current patient does not have any fluid, or expression from the nipple, does not report pain or itching, and has no family history, so cancer is less likely the cause. As such, it would be considered ...

The case is based on acute right quadrant abdominal pain of Mrs. DC who comes to the emergency department. She states that the pain occurred after dinner and has steadily increased. She complains that the pain has increased substantially which has moved towards her back. She also reports to feel bloated and gassy (Yarmish, et al. 2014). The cause of upper right quadrant pain can be due to varied reasons which is based on the general conditions, age, and sex of the patient (Mazzei, et al. 2013). The medical history and physical examination of the patient would help in ...

The Relationship between H. Pylori Infection and Mitochondrial Microsatellite Instability in Gastric Carcinogenesis

Recent research has established that while there are a number of steps that take place in the development of gastric cancer, Helicobacter pylori (H. pylori) plays a major role. However, the mechanism of the influence remains unidentified. Researchers Ling et al. (2016) conducted a study to determine relationships between an infection of H. pylori, IL-8, and mtMSI and whether there is a trigger that causes the infection to progress to intestinal metaplasia, dysplasia, and ultimately to gastric carcinogenesis.   The method used by the researchers included fresh samples from resected gastric cancerous cells and comparison samples of potentially pre-cancerous mucosa; ...

Step1: Patient situation:

The first step in clinical reasoning is to describe the patient in the context of the clinical situation. Ms. Melody King, a 36-year-old female was presented for an emergency laparoscopic surgery for a ruptured appendix. She has a medical history of asthma and depression. Her medication list includes Ventolin, Seretide, Sertraline. Postoperatively, Melody developed peritonitis and was treated with antibiotics and analgesic. The biopsy results of Melody’s sample revealed the presence of adenocarcinoma. Melody will need to undergo a few most test, and till then continue her stay at the hospital. The diagnostic tests: CT scan of chest, ...

Abstract

Paget's disease of the breast is an uncommon kind of cancer of the nipple–areola complex and that is time and again connected to a fundamental in situ or persistent carcinoma. We provide an overview and evaluate the key clinicopathological and healing aspects of mammary Paget's disease. Patients suffering from the Paget disease frequently present with a constant, eczematous skin complaint on the nipple and adjoining areolar skin. Paget's disease of the breast has been acknowledged as a separate clinical unit for over one hundred and twenty years. Since the situation in itself is repeatedly harmless and restricted to ...

Transcriptional regulation of gene expression

Gene expression in eukaryotic cells is regulated at transcriptional, post transcriptional and translational levels (Tomizawa,  Lekstrom-Himes, and Xanthopoulos 17). Transcriptional control is the primary means of regulating gene expression. Eukaryotic transcriptional control functions at three levels: modulation of the activities of activators and repressors; variations in chromatin structure; and effect of activators and repressors on assembly of initiation complexes (Lodish et al. 368). Regulation of transcription initiation is the most widespread form of gene control in eukaryotes. However, in some cases, transcription may be attenuated and regulated at subsequent steps, such as during or after the transcription process (Cooper ...

In reference to the case scenario, there are various lifestyle factors that should be considered during the patient’s treatment course in order to improve her clinical outcome and prognosis. Among the key lifestyle factors include; dietary patterns, level of physical activity as well as behavioral patterns. With regard to this, the healthcare professional should consider the patients dietary habits and educate the need to consume healthy diets such as vegetables, whole grains and fruits (Senkus et al., 2013). In addition, the healthcare provider should foster regular physical exercises in the patient in order to maintain a healthy weight ...

Introduction

Esophageal cancer is among the key health problems that is associated with numerous complications. As such, esophageal cancer is a form of cancer that typically occurs in any part of the esophagus and is among the most severe malignancies (Spechler, 2013). Essentially, this form of cancer is categorized into various types based of the cells involved whereby the most prevalent forms of esophageal cancer are Squamous Cell Carcinoma (SCC) as well as Adenocarcinoma (AC). Among the major risk factors that usually increase the likelihood of developing this form of cancer are smoking, having GERD (Gastro-esophageal Reflux disease), obesity and ...

In reference to the case study, fibroadenomas is the term used in describing the benign condition that could have caused in patient’s breast mass. Essentially, fibroadenomas refers to a benign tumor that is made of the connective as well as the glandular tissue of the breast (Sala et al., 2015). As such, the condition is characterized by solid breast masses that are mainly round, painless and non-tender. Fibroademas usually occur in varying size whereby some are small while other are about eight centimeters in diameter. Fibrocystic breast disease is among the most common breast conditions that affects a ...

Age: 75 years

Medical Record No: 66543N History and physical examination conducted: June 21, 2016 Source: The patients presents his own medical history and is a reliable source Chief Complain presented: Abdominal pain The History of the Present Illness Past medical history The patient presents with diabetes diagnosed 10 years ago, that is well controlled with Metoprolol medication. He also presents with depression and the patient uses Prozac medication for depression management. Mr. X had been previously hospitalized in 2010 due to MI and cardiac catheterization was done therefore, the patient present with a positive history of surgery.

Social history

Family history The patient ...

Amongst the major infectious diseases, hepatitis is one of the most important diseases affecting a huge number of populations worldwide. Hepatitis is majorly caused by virus or other contributors to the inflammation of liver. It can be infectious or non-infectious. It is a big concern to deal with the disease as it is responsible for taking huge tolls of life with its remarkable symptoms in function loss of the liver due to factors like liver scarring (cirrhosis) or liver cancer (hepatocellular carcinoma) in extreme cases (NHS, 2016). Viral hepatitis is considered to be the cause of hepatitis occurrence in ...

The Translation Science Project

The current translation project focuses on colorectal cancer. The translation science project is a contribution to the efforts towards the improvement of the compliance with the screening protocol of colorectal cancer for Latin America patients aged between 50 and 70 years in a community health setting in Miami-Dade. The proposed project’s objective will help to determine how health care staff utilizes evidence-based practices (EBP) CRC screening protocol to improve compliance among Latin population aged 50 to 70 years old. In this project, the population of interest will consist of Latin American patients aged between 50 to 70 years ...

Introduction

Studies relating to lung cancer treatment can save lives and make the lives of cancer patients more comfortable besides increasing the quality of life. According to Lardinois et al., (2003), there are three primary types of lung cancer; they include non-small cell, small cell, and carcinoid lung cancer. Statistically, non-small cell lung cancer, for example, Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma account for the highest occurrences of all lung cancers to a tune of 85% [1]. It has been established that both environmental and genetic factors do contribute to lung cancer significantly. Continued exposure to carcinogens, ionizing ...

Introduction

Research in lung cancer treatment can save lives and improve a patient’s quality of life. There are three main types of lung cancer: Non-small cell, small cell, and lung carcinoid cancer. Non-small cell lung cancer, such as Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma make up about 85% of all lung cancers (Molina, Yang, Cassivi, Schild, & Adjei, 2008). Both environmental and genetic factors are significant in the cause of lung cancer. Chronic exposure to carcinogens, ionizing radiation, and viral infections can lead to alterations of the DNA in tissue lining the bronchial epithelium of the lungs. Furthermore, ...

RESULTS

Section 1 All samples were found to be positive for the anti-Ro antibody with higher than 240 IU/ml, except Sample ID # 13 and 32, which showed lower concentrations (Figure 1.). These samples also exhibited occurrence of Smd and Dn respectively, albeit at low concentrations. Sample Id# 12 and 20 also showed presence of anti-La antibody. The autosera of Patient Id # 32 suffering from SS displays a faint 52kd IgM band, which is representative of 52kd anti-Ro antibody and is fainter in ethanol treatment sample. Patient ID # 42 expressing a higher than 240 IU/L of anti-Ro antibody in the clinical ...

Article review of MRI utilization in Newly diagnosed Breast cancer: a survey of practicing surgeons

In this article, Parker, Schroen and Brenin present the findings of a study they conducted on breast surgeons to determine the practice beliefs which surround the use of MRI in newly diagnosed breast cancer. They state that even though there are guidelines which support the use of MRI in high risk screening, there no guidelines to facilitate the use of MRI in newly diagnosed cancer. They state that breast MRI can identify a disease which is not seen under normal diagnosis procedures such as mammography, frequently leading to a change in surgical therapy. Accordingly, the optimal utility for breast MRI in a group ...

Hilger RA, Richly H, Grubert M, Kredtke S, Thyssen D, Eberhardt W, et al,. Pharmacokinetics of Sorafenib in Patients with Renal Impairment Undergoing Hemodialysis. Int J Clin Pharmacol Ther.; 2009: 47(1); 61-64.

This study was focusing on the use of Sorafenib for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma. It is a molecular inhibitor of a variety of tyrosine protein kinases and Raf kinases. Sorafenib is an oral inhibitor that inhibits the activity of threonine kinases. It has been approved in many countries including United States for the treatment of advanced renal cancer and primary liver ...

Medullary thyroid carcinoma refers to the cancer that affects the thyroid gland starting from the cells that produce a hormone known as calcitonin (Tuttle). The location of the gland is inside the front part of the neck and the cells producing the hormone are referred to as C cells. The pattern of growth of the medullary carcinoma is a bit slow but progressive and usually invades structures that are adjacent. The spreading of the tumor is hematogenous with metastases occurring typically to bone, lymph nodes, as well as the lung. There is variability on the clinical progression of medullary thyroid carcinoma ( ...

Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.

This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...

A medical professional with post graduate qualifications with a major in diagnosing, treating and preventing diseases related to skin, and skin cancer is known as a dermatologist. These professionals are skilled to understand the structure and functions of the skin and the connections that are concerned with skin pathologies and failures of other body parts. People perceive dermatologists to be specialists in treating medical issues; however, dermatologists also deal with beautifying skin problems, for example, wrinkles, scars, and early ageing. Several studies of Asian populations demonstrate pigmentary changes as a major component of early aging . After gaining a medical degree, the dermatologists specialize ...

Specific Aims

Activation-induced cytidine deaminase (AID) encodes a DNA-editing deaminase, which is a group of the Cytidine Deaminase family (Bello). This protein is concerned in somatic gene conversion, hypermutation, and class-switch recombination of Ig (immunoglobulin genes). Activation-induced cytidine deaminase (AID) has been expressed in B cells at germinal center and starts the events, which lead to class switch recombination of immunoglobulin genes and somatic hypermutation. Additionally to this primary responsibility in immune diversification, deviant targeting of Activation-induced cytidine deaminase activity leads to translocations and point mutations of oncogenes linked with B-cell lymphoma. Lately, AID has been related in active DNA demethylation (Sariah). ...

Lung cancer (also called – carcinoma of lungs) is a type of malignant tumor. It emerges from cells paving lungs and bronchi. Usually it takes years for this type of cancer to develop. But if a person gets this type of disease most likely other organs will be affected as well. Lung cancer is a really dangerous for a human, as it is hard to diagnose it and it might be too late to treat it. This disease contributes to the major part of deaths throughout the developed countries. Annually there are about 1 million cases of lung cancer around the world. In addition, ...

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Literature Review

Introduction Dentistry as a branch of medical science has successfully and uniquely combined the principles of human science and the art of healing. The dental profession in particular has changed during the past years due to the review of scientific evidences that emerged in the health fields and medicine that rely on systematic approach. The findings from several literatures suggest clinical practices and other relevant concepts pointing out the recommended frequency of visits to dental practitioners for various types of patients. This includes patients suffering from oral cancer, periodontal diseases, and caries risk. In ...

A review of the article by Jankowska, et al., 2008, titled “Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells” Jankowska, et al in their article published in the journal “Molecular Cancer” demonstrate the expression of hCG-beta in cervical cancer and examine the functional significance of hCG- in-vitro cervical cancer cells by making use of modified U1snRNA to silence the mRNA of hCG-. Silencing of the maturation of mRNA by use of a novel silencing technique results in inhibition of growth and apoptosis of cervical cancer cells. Lipofectamine 2000 ...

Immunity Regulation in Natural Killer (NK) Cells

Introduction Research indicates that lung cancer forms a 24.5% of all the malignant tumors that can happen in the body of a human being. There have been efforts to find the treatment that would eliminate or reduce the spread of cancerous cells to no avail. The procedures that remain as viable options could include surgical resection, which only works to prolong the life of a victim of lung cancer. The natural killer cells can be an option in fighting the spread of cancerous cells. They are nonspecific killer cells, which denotes to their being able to fight all kinds of harmful ...

Cause and effect of cancer

For a common individual cancer is the deathly disease, for which a treatment process that would completely finish it has not yet been found! We fear it as we fear death, because at the end of the day that is what it does to us. It slowly decays our body to the extent that there is nothing left inside us. Cancer refers to a non-communicable disease characterized by uninhibited multiplication of abnormal cells in any part of the body. It is these abnormal cells which, are called cancerous, malignant or tumor cells (medicinenet.com). Types of cancers are further identified by ...

(Author)

Regulation of Xiap Protein in Breast Cancer Breast Cancer Breast cancer is the type of cancer that develops in the tissues of the breast. Two most commonly reported types of breast cancer are “ductal carcinoma” and “lobular carcinoma”. Ductal carcinoma is initiated in the lining of the milk ducts, which are thin tubes involved in carrying of milk from lobules of the breast to the nipple. Ductal carcinoma can be in the form of Invasive ductal carcinoma (IDC) as well as Ductal carcinoma in situ (DCIS). IDC is the most commonly found type of breast cancer ...

Immunohistochemistry

Introduction The Human Papilloma virus (HPV) is an extremely common group of viruses that are found worldwide. There are more than 100 types of HPV worldwide. 13 types of HPV are associated with cancer. They are also termed as high risk type. (WHO, 2013). HPV is transmitted through sexual contact. More than 90% of cases are infected shortly after sexual activity. Cervical cancer is associated with HPV infection that are acquired through sexual contact. 70% of cervical cancer cases are caused by two types of HPV. HPV 16 and HPV 18 are the two strains associated with cervical ...

[Author]

Abstract

The present review is aimed at providing an understanding on how the workplace contributes to the development of skin cancer. Five reviews (3 epidemiological data reviews, 1 meta-analysis, and 1 article) obtained from PubMed, involving a total of at least 3479 mortality and morbidity in skin cancer. These studies agreed on the initiating role of the workplace in the development of skin cancers, both malignant mesothelioma (MM) and non-melanoma skin cancers (NMSC), due to chronic exposure to carcinogens such as asbestos (Rushton, 2012; Boffetta, 2004; Romeo, 2004; ), mineral oils (Rushton, 2012), solar radiation (Rushton, 2012; Hannaford-Turner, Elder, Sim, Abramson, ...

Breast cancer is the most common type of cancer found in women, second only to melanoma. Although breast cancer occurs in both men and women it is far more frequently diagnosed in women. Increased awareness and support for breast cancer on a community and national level as improved the ability to detect breast cancer early, and to diagnose type of cancer accurately and quickly has led to new treatments and increased survival rates.

Background Information

Breast cancer is a type of malignancy that begins in the breast tissue. There are two primary kinds of breast cancer. The first, called ductal carcinoma, forms in ...

Introduction

The human papillomavirus (HPV) is from the papillomavirus family which infects the cells in the skin or the mucous membrane. HPV is a non-enveloped double stranded virus which carries its genetic code from early (E1-E7) and late (L1-L2) proteins. The early proteins promote viral replication while late proteins are responsible for structural support or capsids of proteins. Two viral oncogenes together with the non-structural early proteins (E6-E7) were associated to the transformation of the tumor from benign to malignant stage. The aforementioned proteins influence carcinogenesis by promoting both the retinoblastoma (Rb) and p53 proteins. These proteins regulate cell growth and ...

Introduction

Cancer is a chronic disease in which there is out of control growth of cells. There are over hundred types of cancer, and each type is distinct with the rest in the sense that particular human cells are affected initially.Breast cancer affects the breast tissues, mostly the inner lining of the ducts or lobules supplying milk to ducts (Cedolini et al. 2014). Cancers having their origin in ducts are called duct carcinomas and those having their origin in lobules are referred as lobular carcinomas. Breast cancer is commonly prevailing and alarmingly high incidences of this disease in women all over ...

Abstract

The research paper deals with the problem of Merkel cell carcinoma, chief peculiarities, and the possibility of medical treatment. Disease signs and symptoms are highlighted in the opening and subsequent paragraphs of the paper. The pathophysiology, etiology, manifestations, possible complications, and disease treatment are the focal point of the research paper. The research is based on the opinions of the finest subject-field experts, such as professors, doctors, and scientists. Keywords: Merkel cell carcinoma, medical treatment, disease, complication, cure Merkel cell carcinoma is an aggressive skin cancer usually caused by polyomavirus. Scientists and doctors have not managed to ...

Introduction

Antigen Presentation Antigen presentation plays a pivotal role in the immune system through which pathogenic antigens are processed and coupled along with major histocompatibility complex (MHC), and presented to T cells for their effector response. Macrophages, B cells and dendritic cells are the primary antigen presenting cells (APC’s). Intracellular antigens generated by viruses, or some cytoplasmic bacterial antigens are digested by the host cells and coupled with MHC Class I by Transporter associated with antigen Processing complex (TAP), which transports them to the cell surface and presents to CD8+ cytotoxic T cells (Germain, R 1994). These cells elicit a ...

Introduction

Breast cancer affects the breast tissue. There are two forms of this cancer: one type originates from the ducts and is commonly known as ductal carcinoma while that which originates in the lobules is termed as lobular carcinoma. In women, breast cancer accounts for over 22 percent of all cancers (Suter & Marcum, 2007). The molecular underpinnings of breast cancer are very complex and have different cellular pathways particularly those of cell growth and proliferation. Examples of these pathways include MAPK; TP53; P13K/AKAT/mTOR and RB/E2F (Suter & Marcum, 2007). At the molecular level, these pathways are a representation of molecular mechanisms ...

Abstract

The research paper deals with the problem of whether or not cannabis and cancer are interrelated. There are arguments provided in favor of cannabis stimulating the growth and proliferation of cancer and counterarguments, claiming that not only has marijuana consumption no negative impact on human health, but it also has the potential of being used for medical purposes for treating brain, breast, lung, prostate, blood, oral, liver, and pancreatic cancer inasmuch as it serves as a natural inhibitor of tumor growth as well as providing apoptosis of malign cells. Cannabis treatment may also be used as a legitimate, harmless and far ...

- The cancer to be researched it eye cancer which is a malignancy that starts in the eye and is divided into two groups, intraocular and orbital cancer. - The question for the research include; - Who are the susceptible groups to eye cancer infection in the population? - What is the incidence of eye cancer in the past decade? - Which type of eye cancer is most prevalent among those diagnosed with eye cancer? - Does eye cancer show any pattern of distribution (geographical or racial) or is it randomly distributed among the world’ ...

Pancreatic cancer (PC) is a malignant cancer that originates from cancerous cells in the pancreas. It has been estimated that 90-95% of pancreatic cancers are adenocarcinomas that originate from the exocrine part of the pancreatic tissue. Adenocarcinomas (ductal pancreatic cancer) are tumors that exhibit glandular architecture when observed under a light microscope. Pancreatic carcinoma accounts for fourth highest occurrence of cancer related deaths in the United States. The prognosis for the various stages of pancreatic cancer is poor with an estimated 25% survival rate for a person diagnosed with stage 1, while only 5-6% survival rate estimated for a stage 5 diagnosis according ...

Abstract

Head-and-neck cancer is a term used generally to explain malignancies located in the oral and nasal cavities. Hypopharyngeal, laryngeal, nasopharyngeal, Oral and oropharyngeal, paranasal sinus, salivary gland and nasal cavity cancer are common types of HNCs. This paper describes laryngeal cancer, which is one type of HNC, in terms of facts and figures, causes and symptoms, diagnosis and treatment. The salient facts include: 1100 cases of laryngeal cancer are reported annually, accounting for 25% of HNCs; Laryngeal cancer is associated with smoking and the risk is increased through alcohol consumption; Diagnosis is done through mirror exam or physical exam; symptoms ...

Cancer is a disease that has been reported to claim millions of lives a round the globe and has many forms. Cancer is defined as “a malignant form of tumors, which are tissue masses that arise through mutations in the genes that govern cell growth and division” (Arndt, 2010). Skin cancer is just one of the many types of cancer that affects people and most commonly in the United States. It is a disease whereby cancerous cells are found on the epidermis which is the outer layer of the skin or uncontrolled growth of skin cells. This cancer affects the skin tissues and ...

Report on Vinyl Chloride

Report on Vinyl Chloride The case involves a man who went into a polymerization tanks measuring 8 feet in high and 5 feet wide. The man went into the tank alone at night, and there was no light in the pit. After 20 minutes, the man did not return, and somebody went to check him. The man was found lying in the pit. The person who was looking for the man climbed in order to get the man out, but the person was overwhelmed by the gas. The person immediately shut the open valve feeling dizzy. The person dragged himself ...

Breast cancer is harmful to women and men, can lead to the loss of a breast or can be fatal. Breast cancer refers to a type of cancer that originates from the tissues of the breast especially the inner lining of the milk duct or lobules that are involved in the supply of milk to the ducts (Sariego). Breast cancer just like the other cancers takes place through an interaction between environmental factors and the host who is genetically susceptible. Normal cells usually become cancerous after losing their ability to stop the division process. Breast cancer is divided into two main ...

(Course No.) (City & State) Growing cells are located within defined environmental niches and any area outside the niche is very hostile. Because normal cells lack survival techniques, it leads to anoikis. The tumor development process strives when malignant cells escape from the local issues and resist anoikis. The cells of the immune system play a dual role of stimulating adaptive immune responses against tumor-specific antigens and at the same time promoting tumor angiogenesis and progression. This is through the support of the innate and inflammatory responses (Ravi et al., 2000). Integrins are termed as a family of adhesion ...

Introduction

Smoking causes around 40000 premature deaths yearly in USA and 4.9 million deaths per year world or 8.8 percent of all global deaths (burns 2013). 4000 teens try to smoke for the first time each day. 1000 teen become daily smokers. Smoking is equivalent to poisoning. Tobacco is a deadly mix of more than 7000 chemicals (burns 2013). Death due to smoking is highly preventable. The causes and impacts of smoking are known and avoidable. Smoking is not illegal in most countries around the world. However, its effects are even worse than some illegal substances. Given these alarming statistics, researches ...

Breast cancer is a disease of epithelial cells that line the ducts of the breast. Malignancies of the breast are some of the most common cancers in women (aside from skin cancer) and are responsible for up to one-third of all cancers in women. Mortality because of the cancer is on the decline in the United States due to better detection and treatment. Breast cancer is a clonal disease, meaning that a single transformed cell that eventually expresses full malignant potential causes it. Therefore, it may exist for a long period before it becomes invasive and metastatic (Harrisons, 2008, p.563) The major ...

Abstract

Skin cancers are cancers that affect the skin. These include melanoma, basal and squamous cell cancers. The symptoms include skin color change and appearance of skin ulcers, as well as, alterations in the moles that are on the skin. Smoking and ultraviolet radiations are some of the leading causes of skin cancer. The condition may be treated through radiations, chemotherapy among other means.

Introduction

Skin cancers refer to the types of cancer that affect the skin. These cancers include the basal cell cancer, squamous cell cancer and melanoma. The basal cell cancer is the type of cancer that arises from ...

- Sodium imbalance The normal range for serum sodium levels in adults and older children is 137 to 145 millimoles per litre. A person with more than 145 millimoles of sodium per litre is said to have hypernatremia. A person with less than 137 millimoles per liter is said to have hyponatremia. George’s sodium imbalance could be as a result of lung carcinoma which he suffers from. Lung carcinoma is known to cause syndrome of inappropriate anti diuretic hormone. This syndrome results in the abnormal secretion of anti-diuretic hormone. The increase in the levels of anti-diuretic hormone ...

Introduction

The urinary bladder is a hollow organ in the pelvis that stores urine for a temporary period until it is passed during urination. Bladder cancer is a common cancer affecting the urinary system; and bladder is the most commonly affected cancer site in the urinary system. Most of the bladder cancers originate at the urothelium, which is a layer of mucosa lining the bladder (cancer.net). It is very common in the regions of the Americas, Europe, and Asia. Squamous cell carcinoma is the second most common carcinoma. Approximately, 2% of bladder cancers are adenocarcinomas and 0.3% to0.7% are small cell carcinomas(Medscape).

Epidemiology

In ...

Introduction

The urinary bladder is a hollow organ in the pelvis that stores urine for a temporary period until it is passed during urination. Bladder cancer is a common cancer affecting the urinary system; and bladder is the most commonly affected cancer site in the urinary system. Most of the bladder cancers originate at the urothelium, which is a layer of mucosa lining the bladder (cancer.net). It is very common in the regions of the Americas, Europe, and Asia. Squamous cell carcinoma is the second most common carcinoma. Approximately, 2% of bladder cancers are adenocarcinomas and 0.3% to 0.7% are small cell carcinomas (Medscape).

Epidemiology

...

Abstract

Introduction Display of Data Materials and Methods Results Discussion Conclusion Abstract The aim of this project was to investigate the incidence of follicular carcinoma in follicular lesions as reported by fine needle aspiration (FNA) in King Abdulaziz University Hospital. It was observed that a high percentage of these follicular lesions were benign. Of major concern is that a large percentage of these clients undergo surgery to establish a diagnosis. It is advocated that alternative measures should be adopted to reduce unnecessary surgeries. Hence, reducing cost, morbidity and the psychological impact on the patient of uncertain ...

Abstract

Renal cell carcinoma is a devastating disease that oftentimes results in a poor prognosis because there are few effective chemotherapeutic options. The renal carcinoma cell line 769-P is an ideal in vitro model for investigating novel drug treatments for renal cell carcinoma. Two drugs that may potentially reduce renal cell carcinoma proliferation are Actinomycin D and phorbol 12-myristate 13 acetate (PMA). Both of these drugs have been shown to inhibit cell proliferation in other in vitro models of cancer. This study examined the effects of Actinomycin D and PMA treatment on the proliferation of 769-P cells. Cell viability studies indicate that ...

Skin cancer can be defined as a disease in which malignant cancer cells are found on the surface of the skin. There are three basic types of skin cancer which are named depending on the type of skill cell on which they appear (DeLong and Burkhart 528). The three are; Basal Cell carcinoma, Squamous cell carcinoma and Melanoma (DeLong and Burkhart 528). Basal cell carcinoma, according to DeLong and Burkhart, is described as a non-healing sore on the skin whose cell of origin, though at times unclear, is believed to be the follicular stem cells (528). Squamous cell carcinoma, on the ...

According to Scully (2012), the oral cavity (which includes the lips and the mouth) is one of the most common forms of cancer around the world, with three quarters of diagnosed cases affecting people in developing countries. In those areas, oral cancer ranks as the third most prevalent of all cancers, just after stomach and cervical cancer, and about 378,500 new cases are diagnosed every year. In developed countries, oral cancer is less common, but it still ranks as the eighth most common cancer type, although the frequency varies quite a bit by country. Most oral cancers start ...

Every profession has its own ethical considerations, but the area of social work has some of the most heart-wrenching ethical stories, because when practitioners act unethically, either through neglect or through malice, the effects are so tragic. In this case study, the patient was a 52-year-old single man (never married). Because he had multiple handicaps, he had a social worker serving as his legal guardian. He did have two relatives in the area – two sisters. Both of them took care of their brother as much as they could, but they also had full-time jobs of their own to hold down. Over ...

Introduction

Body cells normally grow, divide, and die in a systematic manner. During adulthood, most cells divide to repair injuries or to replace the dying (worn-out) cells. Some cells, however, grow out of control. These cells are referred to as the cancer cells. Instead of dying, the cancer cells grow out of control (abnormally) and form new abnormal cells. Besides, the cancer cells can invade normal tissues. In most cases, the cancer cells form a mass of body cells that are malignant and have no physiological function, usually called the tumors. When they get into the blood stream or the lymph vessels, ...

LIVER DISEASE

Pathophysiology of the Disease Liver disease is a major concern all over the world. The initial stages are referred to as hepatic fibrosis. In case of severe and critical advancement, the stage is called cirrhosis. In this stage the disease is not reversible; the fibrous is scarred and the hepatic structure is characterized with interconnecting bands (Regenstein & Dickerson, 2006). Normal working of the liver is hindered by the resulting insufficient blood flow and continuous destruction of hepatocytes (Sorrell, Maddrey & Schiff, 2011). The etiological factors which lead to cirrhosis include Hepatitis B, Hepatitis C and abuse of ...

Hepatocellular carcinomas (HCC) exhibit genetic heterogeneity. Most of the HCC tumors are associated with activation of insulin/IGF-1/IRS-1/Ras/Raf/MAPK/Erk and a WNT/Frizzled receptors/β catenin signaling cascade which provides targets for therapy. All the pathways are mediated by genetic mutations and signaling compounds and the loss of regulatory proteins also contributes for tumor generation. Two signaling pathways are involved in the carcinogenesis which includes insulin/IGF 1/IRS 1/MAPK and Wnt/FZD/β catenin pathways. The insulin/IGF-1/IRS-1/MAPK cascade plays a crucial role in regulating regeneration of liver and embryonic development. The constitutive activation of these cascades which is due to IRS 1 over expression leads to HCC ...