Salmeterol is part of a broader group of drugs known as adrenergic agonists; it works specifically by binding to β2 receptors of the adrenergic receptor family, which are activated by the binding of the endogenous neurotransmitters, norepinephrine and epinephrine. The adrenergic receptors are as well part of a broader group of receptors known as G-protein coupled receptors. The G-protein receptor family is composed of a single peptide with seven trans-membrane regions that are attached to a G protein, Gs, Gq, or GI (Harvey & Champe, 2008). The G protein has 3 subunits; the α, β, and γ subunits; the α subunit in the resting state is bound to ...
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