Parkinson’s disease lacks a cure but certain medicines can help manage the symptoms. These medications function to offer a substitute for dopamine, the signaling neurotransmitter in the brain. Carbidopa-levodopa is hitherto the most effective medicine to manage Parkinson’s disease. This chemical moves to the brain and is converted to dopamine. The chemical levodopa is mixed with carbidopa preventing it from being converted to dopamine prematurely out of the brain hence potential side effects such as nausea are lessened. Potential side effects with this medication however include orthostatic hypotension or feeling light headed and nausea. With continued use ...
Essays on Comt
2 samples on this topic
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INTRODUTION
Catechol-O-methyl transferase (COMT) is an enzyme that plays a significant role in the metabolism of dopamine (DA) and amounts to approximately 60% or more of DA breakdown in the frontal cortex . The gene expressing the COMT enzyme could affect cognition and functioning of the brain via its action on dopaminergic function. A polymorphic variation occurs in the coding area of the COMT gene (a Guanine to Adenine replacement), changing the amino acid from valine (Val) to methionine (Met) at the codon position 158 (Val158Met) and consequently influencing the thermal tolerance and stability of the enzyme. Allelic discrepancies in enzyme ...
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