Part 1: Summary
Signaling pathway is a series of biochemical events initiated, after a cell receives extraneous stimuli, by factors such as hormones. The activation of the adapter proteins turns on the connections among the pathways and allows the signal transfer (Flynn). The adaptor protein Crk, for example, influences the physiology of chronic myelogenous leukemia (CML). Many proteins regulate the off and on states by shifting between the trans and cis configurations of a proline switch. In Crk, the cis-trans isomerization modulates the proline switch. The switch is off in the cis state, and the Crk protein is inactive. The switch, however, is on in ...
