Essays on Cyclin E

Prognostic Cancer Biomarkers

The genetic diversity associated with cancer cells are shocking huge; and identifying a suitable prognostic marker is a real challenge. Prognostic cancer markers aims to evaluate objectively a patient’s overall outcome, response to treatment and chances of cancer recurrence. Prognostic markers can also help to select patients for a particular treatments and help predict the beneficial effect of the therapy. DNA, RNA, epigenetic patterns, signaling pathways, proteins, and metabolic biomolecules have been used as prognostic cancer markers. (Mehta et al., 2010)

Given below are few prognostic biomarkers commonly used in cancer medicine:

1. Beta tubulin: Beta tubulin regulates microtubule assembly in the cell. Class III tubulin are expressed by tumor of both neuronal ...

Embryonic stem cell is a crucial factor in the developmental process of a multicellular organism. Embryonic stem cells (ESCs) are derived at early stages during development and eventually give rise to all type of tissues and organs in an animal. The ES cell lines have three properties consisting of self-renewal, primary chimera formation and pluripotency [1]. Pluripotency, a key feature of ESCs, refers to the capacity of a cell to differentiate into several different types of tissues [2]. An array of cellular factors play important role in maintaining pluripotency and determining cell fate in the developmental pathway. Negative effects on these factors may ...

Introduction

Breast cancer affects the breast tissue. There are two forms of this cancer: one type originates from the ducts and is commonly known as ductal carcinoma while that which originates in the lobules is termed as lobular carcinoma. In women, breast cancer accounts for over 22 percent of all cancers (Suter & Marcum, 2007). The molecular underpinnings of breast cancer are very complex and have different cellular pathways particularly those of cell growth and proliferation. Examples of these pathways include MAPK; TP53; P13K/AKAT/mTOR and RB/E2F (Suter & Marcum, 2007). At the molecular level, these pathways are a representation of molecular mechanisms ...