In Tissenbaum and Guarente's research study, they concluded that increasing the dosage of a SIR2 gene is associated with extended lifespan of roundworms, Caenorhabditis elegans (Tissenbaum & Guarente 228). To easily understand their research study, let us discuss a little background abound longevity of C. elegans. In 1997, a research study headed by Kimura, Tissenbaum, Liu and Ruvkun found the gene that potentially regulates the longevity and diapause in Caenorhabditis elegans. In C. elegans, their life cycle after the initial larval stage can proceed to two different stages: either the reproductive stage, or the dauer diapause stage (Hu). In their ...
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