Red blood cells take approximately 120 days to be produced. The process of its production is called erythropoiesis and the place of production is myeloid tissue. For the formation of red blood cells, the haemocytoblast must be present. The existence of Multi-CSF causes the haemocytoblast to progress into progenitor cells. The progenitor cells, on the other hand, will form other cells. This cell may also develop into proerythroblast when EPO is present. Proerythroblast forms basophilic erythroblast which will in turn develop into polychromatophilic erythroblast, followed by normoblast which develops into reticulocyte which eventually becomes erythrocyte. All these developments must ...
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MicroRNAs are small, single-stranded, non-coding, 16–29 nucleotide RNA molecules comprising of an evolutionarily conserved class of endogenous ribo-regulators that regulate gene expression (Wiemer, 2007; Garzon et al., 2009). They were discovered in 1993 in the nematode Caenorhabditis elegans (Espinosa & Slack, 2006). Currently, 4167miRNAs are listed in the miRNA registry and 474 human miRNAs have been identified (Wiemer, 2007). MicroRNAs are crucial for the development of vertebrates due to the fact that depletion of the components of the miRNA processing pathway, or interfering with maturation of miRNAs, is not compatible with life (Wiemer, 2007). The miRNA ...
MicroRNAs are small, single-stranded, non-coding, 16–29 nucleotide RNA molecules (approximately 22 nucleotides in length) comprising of an evolutionarily conserved class of endogenous ribo-regulators that regulate (modulate) gene expression (Wiemer, 2007, p.1529; Zhang et al., 2006, p.9136; Garzon et al., 2009, p.168). They were discovered in 1993 in the nematode Caenorhabditis elegans (Espinosa & Slack, 2006, p.131). Currently, 4167 miRNAs are listed in the miRNA registry and 474 human miRNAs have been identified (Wiemer, 2007, p.1530).
The miRNA genes are dispersed across the genome in gene clusters or as single genes. At least 50% of the miRNA genes are ...
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