Rocky mountain spotted fever is tick-borne infection. In endemic areas, the prevalence of the diseases is 15 per 100,000 persons. The disease is characterized by sudden onset of fever and headache. It is caused by gram-negative intracellular bacteria Rickettsia rickettsii. The bacteria have a high predisposition for the endothelial cell. Actin protein polymerization in the cells is important for the spread of bacteria from one cell to another. (Raoult & Parola, 2007) The bacteria cause lymphohistiocytic vasculitis and necrosis of the infected cells. It typically takes 5-7 days from the day of tick bite to the onset of symptoms. ...
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Introduction
Microbiology is a fundamental branch of medical science from which the discovery and treatment of various microbial causing diseases takes place. In terms of practice, Obstetrics and Gynecology are unified aspects of medical specialty that deals with management of pregnancy and care of female reproductive health. With the two concepts employed, more sophisticated women’s health issues can be effectively addressed. The role of microbiology in OB/GYN practice includes detection, prevention, and treatment of several bacterial infections among women including the common ones such as Trichomonas vaginalis and Chlamydia Trachomatis. These bacterial infections do not often manifest in symptoms ...
Assignment 2
PART A - (Total 15 marks)
Cephalexin and Gentamicin The mechanism of action of amoxicillin is focused on the prevention of the synthesis of the bacteria’s cell wall through the binding and inhibiting of the cell wall transpeptidases (Katzung, Masters, and Trevor, 2012). Specifically, it attaches to the penicillin-binding protein 1A found in the cell wall of bacteria. Then, the agent disintegrates the lactam ring to allow the acylation of the penicillin-sensitive transpeptidase C-terminal domain. The formation of the cross-link of the linear peptidoglycan strands is prevented by the inactivation of transpeptidases. Since the third and last stage ...