Essays on Epithelial

Literature Review:

Factors and predictors of persistent lesion (positive hr-HPV DNA test or abnormal cytology) after treatment of high grade cervical intraepithelial Neoplasia with large loop excision of transformation zone (LLETZ) {Author Name} {Institution Affiliation}

Introduction

The Human Papillomavirus (HPV) infection is the primary factor that increases the risk of the cervical cancer development and cervical intraepithelial neoplasia (CIN) in the uterine cervix (Soderlund-Strand et al., 2014). Approximately 150 diverse types of HPV have been discovered, and most of them are carcinogenic. Persistent infections of high-risk HPV must lead to the development of high-grade cervical intraepithelial neoplasia (CIN 2 and 3), and ...

Step1: Patient situation:

The first step in clinical reasoning is to describe the patient in the context of the clinical situation. Ms. Melody King, a 36-year-old female was presented for an emergency laparoscopic surgery for a ruptured appendix. She has a medical history of asthma and depression. Her medication list includes Ventolin, Seretide, Sertraline. Postoperatively, Melody developed peritonitis and was treated with antibiotics and analgesic. The biopsy results of Melody’s sample revealed the presence of adenocarcinoma. Melody will need to undergo a few most test, and till then continue her stay at the hospital. The diagnostic tests: CT scan of chest, ...

Abstract

Paget's disease of the breast is an uncommon kind of cancer of the nipple–areola complex and that is time and again connected to a fundamental in situ or persistent carcinoma. We provide an overview and evaluate the key clinicopathological and healing aspects of mammary Paget's disease. Patients suffering from the Paget disease frequently present with a constant, eczematous skin complaint on the nipple and adjoining areolar skin. Paget's disease of the breast has been acknowledged as a separate clinical unit for over one hundred and twenty years. Since the situation in itself is repeatedly harmless and restricted to ...

Transcriptional regulation of gene expression

Gene expression in eukaryotic cells is regulated at transcriptional, post transcriptional and translational levels (Tomizawa,  Lekstrom-Himes, and Xanthopoulos 17). Transcriptional control is the primary means of regulating gene expression. Eukaryotic transcriptional control functions at three levels: modulation of the activities of activators and repressors; variations in chromatin structure; and effect of activators and repressors on assembly of initiation complexes (Lodish et al. 368). Regulation of transcription initiation is the most widespread form of gene control in eukaryotes. However, in some cases, transcription may be attenuated and regulated at subsequent steps, such as during or after the transcription process (Cooper ...

Summaries

Goel, Reema et al. 2015. Highly Reactive Free Radicals in Electronic Cigarette Aerosols. Chemical Research in Toxicology 28:9 (1675-1677). In this reported scientific study, a group of researchers from the Pennsylvania State University investigated whether the aerosol produced by an e-cigarette contains reactive, short-lived free radicals. Initially, the researchers proposed that the e-cigarette vapor may contain high concentrations of free radicals, presumably from the presence of high concentrations of free radicals from conventional cigarette smoke. It must be pointed out that reactive, short-lived free radicals, such as reactive oxygen species and reactive nitrogen species, are potentially toxic to organisms, ...

Smoking electronic cigarettes (or e-cigarettes), colloquially known as vaping, has become a rapid global trend. In fact, about a fifth of Americans aged 25 to 44 are using e-cigarettes (Hwang et al. 667). E-cigarettes are battery-powered devices that use a solution of nicotine, flavorings, and humectants, to produce an aerosol, which will be inhaled by the user. The popularity of smoking e-cigarettes may be due to various motivations, but the most practical reasons are to help the user quit traditional cigarette smoking and to allow the user to use nicotine within non-smoking areas (Kalkhoran & Glantz 1). However, the popularity ...

Abstract

Worldwide, ovarian cancer is ovarian cancer is the sixth most diagnosed cancer and is responsible for the most deaths annually than any other disease of the female reproductive system. It has a poor prognosis because the symptoms are vague even into Stage IV of the disease. Epithelial ovarian cancer constitutes about 90% of diagnosed cases. Research has demonstrated that hormone therapy, chronic pelvic inflammation, and BRCA1 and BRCA2 germline pathogenic variants are factors in the etiology of ovarian cancer. BRCA1 and BRCA2 is also associated with breast cancer, pancreatic cancer, fallopian tube cancer, prostate cancer, and primary peritoneal cancer. ...

Introducing the Microorganism

Candida albicans is a human microbiome member. It is opportunistic in nature and exists as a non- harmful resident of the genitourinary tract in 70% and of oral cavity in 75% of humans. It has shown opportunistic behaviour leading to infections in case of individuals whose immune system is compromised (immunocompromised). C. albicans is mainly responsible for 2 types of infection: superficial candidiasis like vulvovaginal or oral infections and systemic life-threatening infections. C. albicans has been observed to cause vulvovaginal candidiasis in approximately 75% of women. C. albicans is an obligate and diploid organism possessing 8 pairs of chromosomes, ...

{Author Name [first-name middle-name-initials last-name]} {Institution Affiliation [name of Author’s institute]}

Diuretics targets to lower sodium and water reabsorption that may lead to enhanced water excretion. The main aim of diuretics is to reduce the fluid volume inside the body and maintain the electrolyte and water equilibrium. These agents are used for managing the pathological conditions including hypertension and edema such as cardiac congestion failure, liver and kidney problems, and glaucoma. It also helps in processing and regulating the blood pressure by eliminating the excessive salt from the body which slows down the cardiac muscles to impel the ...

The administration of proper medication is essential to the treatment of a health complication. As such, medical practitioners need to enforce proper measures in the issuance of medicine to enhance the betterment of patients (Bojesen et al. 375). The purpose of this study is to evaluate the value of medicines through the utilization of a case study. This study will be in line with the code of conduct for Oncologists since the medical practitioner in this scenario deals with cancer patients. Since the maintenance of confidentiality is essential to the success of the medical practice, the practitioners’ and patient’ ...

Introduction

Cystic Fibrosis (CF) is the most prevalent genetic disorder in the Caucasian population, with an incidence of 1 in 2500 births. CF is a disease that affects many organs including the upper and lower respiratory tracts, pancreas, intestines and reproductive system. Over the past 20 years, our understanding of the manifestation and management of the disease has progressed dramatically. CF was once considered a condition of childhood and there was very little expectation that children would enter adult life. However, CF has become a multisystem adult disease with the increased survival attributable to advancements in standardized treatment, introduction of ...

Article #1:

The article focussed on the breeding behaviours of emperor penguins that are recently discovered with the help of satellites. Mostly it is believed that penguins lay their eggs on sea ice that is fast and stable and that remains intact under the chick fledge. Fretwell and co-workers conducted this study on forty-six colonies emperor penguins. The recent observation revealed that few colonies of emperor penguins breed on ice-shelves instead of sea ice. Due to rapid climate changes and the incidence of ice melting the penguin population has declined and very close to extinction. It is a big concern that ...

Differentiating stem cells into type II Pneumocytes

Type II Pneumocytes is also referred to as type II alveolar (ATII) cells. It is responsible for the production of the surfactant molecule that helps maintain the elasticity of the lungs and reduce the surface tension of the pulmonary fluids. These cells can be derived from murine Embryonic Stem Cells (ESCs) to promote lung regeneration and repair in case of an injury. The cell engineering can also help treat lung diseases. According to Polak et al. (2006), previous experiments for obtaining ATII from ESCs had yielded low cell yield. This led to the development of an elaborate three-step-strategy that ...

Abstract

Cancer of the lungs is among the leading causes of cancer in the world. It has two forms; small cell lung cancer (SCLC), and non-small-cell lung cancer (NSCLC). NSCLC constitutes about 85% of cases of lung cancer. Epidermal growth factor receptor (EGFR) and its mutations are found to have an important role in this cancer. Therefore, EGFR tyrosine kinase inhibitors (TKIs) can work effectively against NSCLC. Gefitinib, which is a first generation TKI, and afatinib, which is a second-generation TKI, are effective as a first-line therapy for advanced NSCLC. Erlotinib is effective as a second-line therapy for advanced NSCLC. ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...