Essays on Fibroblast

Cell culture is an in-vitro technique of cultivating cells under controlled conditions and in sterile conditions. The technique was first developed by Ross Harrison in 1907. During the process of cell culture, the cells are detached from their tissue of origin and segregated from each other, either by mechanical or enzymatic means. The detached cells are then transferred before culturing them in cell culture plate or flask. The first generation of producing cell through this method is called primary cell culture. The cells from the primary culture are transferred to a new culture plate with a fresh medium to ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...

In the process of wound healing, angiogenesis is also known as neovascularization. The process commences in lined with the proliferation of the fibroblast when the endothelial cells mover towards the wound site. Oxygen and other nutrients are required for the formation of epithelial cells and the activity of fibroblasts. In comparison to the fibroblast and epidermal mitigation, angiogenesis is crucial for other stages of wound healing. The process of angiogenesis is complex and occurs in the following stages: Latent period: In this stage, vasodilation and premeabilisation are known to permit leukocyte extravasation during the haemostatic and inflammatory phase. Decontamination ...

The chicken limb (wings) develops and buds out from the lateral plate mesoderm at typical locations along the sides of the embryo. These limbs grow with regional specification that includes distinct anterior-posterior and dorsal-ventral pattern. The limb buds out because of the interaction between the mesenchyme and apical ectodermal ridge (AER). The signals sent from the AER maintain the progress zone in the mesenchymal layer. The progress zone has cell in highly proliferative and undifferentiated state. This knowledge can be used to produce higher number of chicken wings from fewer chickens.

There are certain compounds that are known to ...

Formation of bone during foetal development occurs through the process of ossification. This process is extremely important to proper bone length, density, and uniform skeletal formation. It is driven by a complex network of genes that code for signalling proteins whose function is to turn the ossification process on, off, or slow it down. Defects in these genes can cause problems with the ossification process, and can lead to conditions of skeletal dysplasia (improper formation of bone). One such condition is Achondroplasia, one of the most common forms of dwarfism, or congenital short stature (Lister Hill National Centre for Biomedical ...

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Abstract

Asthma and allergic reactions result in inflamed and swollen lung airways. Asthma is of two types, atopic and non-atopic. The asthma symptoms include excessive production of mucus, coughing, tightness in chest, wheezing, and difficulty in breathing. The triggers for atopic asthma are allergens and the hyper-responsiveness of IgE immunoglobulin. Genetic factors are involved in non-atopic asthma that relies on the propensity of developing asthma and hypersensitivity of airways. Epithelial cytokines, macrophage, eosinophils, and T cells collectively influence the fibroblast production resulting in muscle mutagenesis and bronchial ...

Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway

Many lung inflammatory diseases present pulmonary fibrosis as one of the symptoms, which is characterized by shortness of breath, chronic coughing and discomfort in the chest. It causes modifications of the lung tissues due to overgrowth, hardening and scarring. This occurs mainly due to deposition of collagen, an extracellular matrix (ECM) protein, whose turnover is regulated by fibroblast. Fibroblast is an important cell regulator that is enlisted by a site of injury. This process is driven by release of transforming growth factor-β (TGF-β), platelet-derived growth factor, interleukin-6 (IL-6), and IL-8/CXCL8. Previously, fibroblast was thought to express no or very ...

The musculoskeletal system is responsible for all body movements. The skeletal component of the muscular system provides a structural framework for the body, which protects the internal organs and provides the shape for the body. It acts as the storage for calcium and phosphorus and plays a part in mineral homeostasis(Davidson, 2002)

Functions of the skeletal system(Haywood, 2008)

The role of the skeletal system can be classified into five categories: protection, structural support, movement, mineral and chemical storage and blood cell production. - Protection: The strong material that makes up bones protect the internal tissues and organs of the body like the brain, ears, eyes, spine, ...

Abstract

Adequate nutrition is required for optimal wound healing. The normal processes that allow the progress of wound healing are disrupted due to nutritional deficiencies. Increased infection rates and decreased wound tensile strength are associated with malnutrition. Chronic on-healing wounds are formed in malnourished patients or individuals. Such patients can develop infections, pressure ulcers, and delayed wound healing. Morbidity and mortality among malnourished patients with chronic wounds constitute a serious clinical concern. Wound healing is considered as a complex process. It is the process of replacing injured tissue with new tissue (produced by the body). Production of new tissue is associated with ...

Abstract

Bones are formed through a process known as osteogenesis from three different lineages. This process takes place through two different methods, which are intramembranous ossification and endochondral ossification. A large increment in bone mass takes place in childhood, as well as puberty, through the formation of endochondral bone. At this point, growth hormones are known to play a role. This paper will focus on the process of cartilage and bone formation and the stimulation of bone formation by the growth hormone. There are a number of factors that regulate the formation of bone, while growth hormone affects a number of factors related to ...

Embryonic stem cell is a crucial factor in the developmental process of a multicellular organism. Embryonic stem cells (ESCs) are derived at early stages during development and eventually give rise to all type of tissues and organs in an animal. The ES cell lines have three properties consisting of self-renewal, primary chimera formation and pluripotency [1]. Pluripotency, a key feature of ESCs, refers to the capacity of a cell to differentiate into several different types of tissues [2]. An array of cellular factors play important role in maintaining pluripotency and determining cell fate in the developmental pathway. Negative effects on these factors may ...

INTRODUCTION

The human body consists of tissues and organs that contain over 200 different cell types.1 these cells carry out all the functions required for viability and reproduction. It was argued long ago, that in some tissues, the differentiated cells have a shorter life span and that they are not able to self -renew.2 This led to the notion that such tissues are maintained by cells that have an extensive renewal capacity, and the ability to differentiate and generate daughter cells. These cells were termed as ‘stem cells”.2 Stem cells generate only the differentiated lineages of the tissues they reside in, ...

Compare and Contrast On IPS Papers

All the four papers Takahashi-miPS, Takahashi-hiPS, Park-hiPS and Yu-hiPS respectively induced the four genes (OCT4, SOX2, KLF4 and MYC) and reprogramming the differentiated somatic cells to produce IPS pluripotency cells. In the first paper, the authors found a combination of factors to make the IPS cells. The authors selected the 24 genes for factors that induce pluripotency in somatic cells. Afterwards, all the 24 genes were inserted into the mouse embryonic fibroblast (MEFs) by using retroviral transduction. The cells were cultured on STO feeder cells in ES cell medium containing G418. The authors obtained 24 colonies, and then the authors ...

Outline

Introduction

Epidemiologists’ concerns

Reflection on epidemiologists professionals view points

Synopsis of each point of view

Conclusion

Medicine: Public Health Issues Introduction World Health Organization each week publishes a free News letter called, ‘Weekly Epidemiological Records. Pertinent trends in epidemiology are discussed from a professional perspective giving readers insights into how they predict the progress of disease and their effects on the population. In the following pages of this document the writer will highlight some of these concerns relating reflections while a synopsis is developed.

Epidemiologists’ concerns

A recent research regarding the most recent Weekly Epidemiological Records ranging from 4th February to November ...