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Definition: Proliferative verrucous leukoplakia (PVL) 2, 3 is a rare oral leukoplakia characterized primarily by chronic proliferation (4.4-11.6 years1), exophytosis, confluence, refractoriness to treatment, and extremely high cancerization. It is referred to plainly as ‘oral leukoplakia’ (OL) before 20041. Thereafter, it is called PVL. The WHO classified it among the “potentially malignant disorders”2. When multifocal1, 3, it can be found in the buccal mucosa, gingiva, alveolar ridges, and tongue. Epidemiology: Oral white lesions have a prevalence of 24.8% with 0.2 to 3.6% of which constitutes leukoplakia2. Over 86% of PVL becomes cancerous in 4.73 to 6.12 mean years (range: ...