Parkinson’s disease is a common neurological disorder. It affects approximately 1% of individuals over the age of 60 years. It cases a form of disability which is progressive. However, the disability can be slowed down but not halted by treatment (Hauser, 2013). Neuropathology findings in the disease include the loss of pigmented dopaminergic neurons in the region of the substantia nigra pas compacts. There is also the presence of Lewy bodies and Lewy neurites (Lee et al, 2009). In most cases of Parkinson’s disease, a combination of genetic predisposition and environmental factors has been implicated in the evolution of the ...
Essays on Globus Pallidus
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It was originally thought that basal ganglia were responsible for voluntary motor movements, and movement disorders were associated with pathological changes in the basal ganglia. However, it was found that the basal ganglia are associated with different cortexes with distinctive circuits, which are called loops, so a pathological transformation of tissue can manifest as a psychological or motor disorder, depending on the loop affected. The cortico-basal ganglia-thalamocortical loop is a one-way circuit that allows the basal ganglia to receive input from the cortex and send output via the thalamus back to different regions of the cortex. Pathological changes in this loop are ...