Essays on Immune Response

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Immunotherapy in Treating Human Cancer

The immune system of our body is a complex network of tissues, cells, and organs that act mutually to protect our body from unknown foreign trespassers. It recognizes the harmful particles entering the body and facilitates the destruction of those particles in order to shield the body system from any ailment. Due to any complexity or disturbance often the immune system targets the wrong particle considering it as a dangerous particle and this anomaly of the immune system may result in various autoimmune diseases like arthritis, allergies, malignancies, and AIDS (Understanding the ...

ANATOMY OF URINARY TRACT INFECTIONS

The urinary tract, simply put, is the bodies system of drainage through which excess water and wastes are removed from the body. It is a multi-organ system consisting of the two kidneys, two ureters, the bladder and the urethra. The kidneys are small organs that assume the shape of a bean and are equivalently the size of a normal human fist. They are located below the rib cage, each of them on either side of the spine. Wastewater (urine) moves from the kidneys downwards through two narrow tubes known as ureters, and it is then stored in the bladder, ...

Abstract

Systemic lupus erythematosus (SLE), otherwise known as lupus, is an autoimmune disease caused by varying and often unknown sources. There are different types of lupus, with SLE being the most common. Other types include lupus nephritis, cutaneous lupus erythematosus, drug-induced lupus, and neonatal lupus. SLE can affect different organ systems including the skin, kidneys, liver, blood cells and brain. There is no direct known cause for this disease, but it is thought to be caused by a combination of factors such as certain medications, hormones, genetics and the environment. There are currently few treatments available for this disease and ...

Immune System

(Author, Department, University,

Immune System

Introduction

The human immune system is a complex system consisting of a network of numerous cells and cell types, tissues, and organs working together to defend the human body from foreign bodies such as invading microorganisms, infections, and tumors, while ignoring the normal working and healthy parts of the body.

Discussion

Working of the immune system The immune system has different ways of identifying problems, communicating with other cells, and performing their activities. The immune system has the ability to distinguish healthy cells from unhealthy cells as it can recognize a number of different “danger” cues ...

Introduction

There has been a lot of interest between physical health and mental illness. There is a bidirectional relationship between physical health and mental health (Canadian Mental Health Association, 2008). People who are diagnosed with severe mental illness are faced with a higher likelihood of developing various physical conditions, some of which are fleeting while others are chronic (Canadian Mental Health Association, 2008). Additionally, the people who are diagnosed with certain conditions that affect their physical health have a two-fold risk of developing anxiety and depression when compared to the other population (Canadian Mental Health Association, 2008). The correlation between ...

Seminar: Inflammatory and Immune Mechanisms in Lymphatic Vascular Disease

The YouTube video presented by David Zawieja, talks about immune and inflammatory mechanisms that occur in Lymphatic Vascular diseases. The lymphatic system has a significant role in various essential mechanisms inside the body such as edema resolution, fluid and macromolecular homeostasis, inflammation and antigen trafficking. The primary of the Lymphatic function involves the transportation of Lymphatic substances from the interstitial spaces between the tissues via lymphatic capillary network and nodes that terminate into the venous blood inside the veins. The most significant segment of the lymphatic function is the flow of lymph through multiple nodes. The immune cells like ...

Biomolecules serve different functions in a cell. The three major classes of biomolecules in the cell are: proteins, nuclei acids and carbohydrates. These molecular structures serve nearly similar functions in most organisms. Though the function of protein in forming cell architecture, signaling and communication is well known, little is known about the role of carbohydrate in communication. Nevertheless, it goes un-denying that carbohydrates are indispensable for cellular communication and signaling, just like proteins and nucleic acids. The paper titled, Carbohydrates in Cell Recognition, by the authors Nathan Sharon and Halina Lis, is a good review that elucidates the significance ...

Genetically modified plants have always been a debatable topic surrounded by many controversies. Different research workers have put forward different hypotheses regarding them. Some stand for them, while many are against. The genetically modified crops might have proved to be a boon for many, but at the same time they have brought about much worse effects to the environment. The genetically modified crops are known to harm the natural flora and bring about adverse effects on agriculture too. The changes that are brought about at the genetic level of the plants bring in some changes in their natural character ...

Lignin Chemistry

Lignin History Lignin is a plant-derived biopolymer with several applications. It is considered an effective alternative to chemically synthesized plastics that pose serious environmental problems during manufacture and disposal. Lignin is often obtained as a byproduct in paper and pulp manufacture. Lignin has to be dissolved to obtain cellulose from wood. In 1838, Anselme Payen discovered that wood contained cellulose, and oxidizable coatings (later called lignin) that bind the cellulose together (McCarthy and Islam, 2000). This coating material could be removed from wood after acid treatment and washing with an aqueous alkali solution (McCarthy and Islam, 2000). Later, several ...

Major Achievements in Biology

Researchers and scientists are always intrigued by biological processes and activities, and strive to utilize them for benefit of mankind. Antibiotics, monoclonal antibodies, vaccines and several therapeutic agents, high yielding as well as disease tolerant plants and animals are all results of extensive research in the fields of cell and molecular biology, immunology, biotechnology and genetic engineering. Treatment to several diseases, even genetic disorders are available today only due to breakthrough discoveries in biology. Three such important discoveries are revelation of structure of ribosomes through X-ray crystallography, identification of tumor specific antigens (TSA) expressed on the surface of cancer ...

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This Lot in Life is true for me

12, Main Street, Maryland Dear Amanda, Hope you and your 1-year-old baby are doing well. I just wanted share some great news with you- I am expecting my first child and am in the fourth month of pregnancy. As over the moon as me and my husband are, what is keeping me grounded is the morning sickness. Ouch! Now I understand how exciting and at the same time tough pregnancy can be and I wonder how you went through it all so smoothly just last year. I am also confused about one very important thing about ...

Immunizations in Children

According to World Health Organization (WHO), “Immunization is the process whereby a person is made immune or resistant to an infectious disease, typically by the administration of a vaccine” (World Health Organization). This definition of WHO can be further elaborated by saying that the concept of immunization works by stimulation of the immune system. The immune system performs the function of protecting the body against disease causing agents. In its healthy condition, the body’s immune system has the ability to recognize any invading microbe. The leucocytes identify the microbes and produce antibodies against them. These antibodies are capable ...

Hepatitis type B viral infection is a common and serious disease that is caused by the hepatitis B virus (HBV). HBV is a DNA virus with partial double strands and belongs to the Hepadnaviridae family. One-third of the world’s population is believed to have been infected by HBV of which 6% have chronic HBV infection. Depending on the rate of infection and carrier rate, the world is divided into low, medium and high endemicity regions (Franco et al. 75). The HBV resides in the bodily fluids of an infected individual and is transmitted via the same (Aspinall et ...

Vitamin D deficiency during pregnancy: Effects, treatment and the outcomes

The aim of this study is to evaluate vitamin D deficiency in pregnant women and its impact on pregnancy course, the best way of management, and the outcome of this management Bone metabolism in humans is associated with a complex steroid hormone system which comprises of vitamin D (Harvey, et al. 2014). Many reports have suggested the potential benefits of vitamin D across therapeutic areas including vascular health, placental function, metabolism, and immune function (McAree, et al. 2013). Data based on biological and clinical findings suggest the key role of vitamin D in women reproductive health. However, there is ...

The American College of Obstetricians and Gynecologists, the American Academy of Primary Physicians, the American Academy of Pediatrics, and the World Health Organization recommend that mothers exclusively breastfeed their infants for the first six months after delivery (Stuebe). In fact, the World Health Organization states that even after solid foods are started at six months, the mother should continue breastfeeding her child for at least two years or as long as she is able to produce milk (Breastfeeding Action Group 1). These organizations are quite correct in issuing these recommendations for as opposed to formula milk, breast milk and ...

Introduction

HIV is one of the most deadly viruses affecting the human immune system. Scientists across the globe work day and night to search for the cure of the HIV bit to date no solution has ever worked. Despite there no cure for HIV, scientists have developed various treatments to assist the victim live longer and fight opportunistic infections. The paper discusses the case of a young female who had other symptoms diagnosed with HIV.

Common modes of HIV transmission in the developed countries and the populations at a greater risk of acquiring HIV

The HIV infection is transmitted through open cuts and breaks in the skin. It is also transmitted through mucous membranes, such as the ones inside ...

HCV or Hepatitis C virus infection has over 5 million people affected in US (Chak, et al., 2011) and over 120 million people worldwide hence a global health problem. This virus belongs to Hepacivirus genus and Flaviviridae family (Lindenbach, et al., 2007) with six genotypes and with more than seventy subtypes. In approximately 85% infected individuals it may be unresolved, hence representing a significant hepatocellular carcinoma and liver cirrhosis cause. It is viewed as commonest cirrhosis cause and chronic liver disease in the world. It also represents the main liver transplantation cause in USA, Europe, and Australia (Thimme, et ...

Immunogenic cell death: the role of SAGE

Immunogenic cell death: the role of SAGE

Introduction

Millions of cells are always being removed in the human body not only to regulate and coordinate the body’s biochemical pathways but also to keep the cells healthy. This particular systematic removal of cells occurs through a selective mechanism called cell death or apoptosis process. Apoptosis is not a new concept in the understanding of the biological workings of the body. This homeostatic death of body cells has been defined as a tolerogenic or a non-immunogenic event for many [1]. However, new discoveries have unearthed the existence of a different concept ...

Immunogenic Cell Death: The Role of RAGE

Introduction Millions of cells are always being removed in the human bodyin order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

Hepatitis B virus do not need presentation - its statistics tell about it more as there are more than two hundred million infected people in the world (Sundaram and Kowdley, 2015). In many patients hepatitis B infection leads to the development of the liver cirrhosis and other complications, can cause decompensation of the liver function and lead to death. Prevalence and malignant course of this infection make it a major challenge for modern medicine. Reviewed article lists and shows clinically proved and effective methods of the hepatitis B management. The discovery of a vaccine became the turning point in ...

Introduction

Millions of cells are always being removed in the human body in order to regulate biological pathways and keep cells healthy through a particular mechanism called cell death or apoptosis. Through apoptosis, such homeostatic death of cells has been defined as a tolerogenic or a non-immunogenic event for many years [1]. However, during the past few years, scientists have discovered the occurrence of a different concept of cell death – immunogenic cell death (ICD), where the death of a cell stimulates a response from the immune system against antigens of a dead cell, and this mechanism of cell death may ...

Celiac disease is a condition where the immune system reacts to gluten, a type of protein in barley and rye. It is an autoimmune disorder, this occurs when the immune system do not function well, and starts to attack the organs and the tissues. The immune system of the body is designed to guard against foreign invaders. When people with this condition eat foods with gluten, the immune system create antibodies to this protein attacking the lining of the intestines. The causes of the inflammations in the intestines end up damaging the villi on the ...

- Non-specific immunity provides the first line of defense against infection. Non-specific immune responses are directed towards a wide range of pathogens, for example, the epithelium provides a physical barrier to the entry of pathogens in addition to producing other antimicrobial factors. Specific immunity takes some time to develop. It allows for a response directed towards a specific antigen. Innate immunity is nonspecific. It provides the first line of defense against infection. Its components include macrophages and neutrophils; barriers like skin, and antimicrobial substances synthesized by the body. Acquired immunity is highly specific. It involves antigen processing and presentation, which induces the production ...

Introduction

CD4 is a cellular immune response co-receptor that raises the avidity of relationship between an antigen-presenting cell and a T-cell through interaction with non-polymorphic parts of the complex between T-cell receptor and major histocompatibility class II molecules. It directly contributes to transduction of signal via cytoplasmic relationship with the lymphocyte kinase. CD4 also plays a role as the high-affinity receptor for attachment of cells as well as entrance of HIV. The CD4 extracellular part consists of domains that resemble immunoglobulin D1 to D4. This component of the CD4 has been qualified as a recombinant soluble protein, and crystal structures have been identified for ...

Severe acute respiratory syndrome is a life threatening condition that is caused by a virus from the Coronaviridae family. The SARS virus is believed to have originated from the Guangdong province of southern China before spreading to Hong Kong, Canada and the United States of America. The virus has an incubation period of 2 to 7 days but it may last up to 10 days. Like other respiratory disease, SARS is spread through direct contact; long range and short range. The major agent of transmission is the droplet nuclei. The symptoms of the disease include: fever, chills, malaise, cough, dyspnea and ...

Cortisol is a steroid hormone synthesized in adrenal glands with a myriad of functions mainly in the endocrine and immune systems, and produced during stress circumstances. Under normal conditions, stimuli such as a pathogen release immune proteins called interleukins, which further activate T-lymphocyte cells. T-cells multiply to amplify the immune response and ultimately attack the pathogen (Abbas, 2014). Other immune responses are simultaneously activated, e.g. the complement system. The complement system exerts its functions through three pathways: classical, alternative or lectin pathways. The main activators of the classical pathway are antigen-antibody complexes, which trigger a series of events mainly mediated by complement proteins ...

HIV infection is slowly progressive disease caused by the human immunodeficiency virus (HIV). The virus affects the immune system cells that have receptors on their surface CD4: Helper T cells, monocytes, macrophages, Langerhans cells, dendritic cells, microglia. As a result of the work of the immune system is suppressed, is developed acquired immune deficiency syndrome (AIDS), the patient loses the ability to defend against infections and tumors that occur secondary opportunistic diseases that are not typical for people with normal immune status.

Etiology

HIV is a human immunodeficiency virus, belonging to the family of retroviruses, lentivirus genus. The HIV genome contains a ribonucleic ...

The binding of antibodies to red blood cells can lead to potentially fatal outcomes such as hemolytic transfusion reactions, autoimmune hemolytic anemia, and hemolytic disease of the fetus/newborn.1 Information regarding the first steps of hemolytic transfusion reactions is well documented. It is, however, unclear why the severity of hemolytic transfusions experienced by different individuals ranges from mild to very severe.2 The pathophysiology of the final pathways and downstream events of red blood cell hemolysis are also yet to be fully elucidated although research is ongoing.2 A recent study by Liepkalns et al. (2012)1 has reinvigorated debate on the ...

(City, State)

Introduction

Tuberculosis or TB refers to a common, deadly, and infectious disease that is caused by a number of mycobacteria strains (Kumar, et al., 2007). The most common mycobacterium that causes TB is the Mycobacterium tuberculosis. TB usually affects the lungs, although it is also possible for the other body parts to be affected. The disease uses air as the medium of spreading the infection when infected people sneeze, cough or transmit fluids from the respiratory organs through air. Some of the symptoms associated with the different TB variant, as well as TB stages, include chills, loss of appetite, fever, ...

Introduction

Allergy is an immune system disorder. Allergy or allergic reaction is a hypersensitivity to otherwise innocuous substances present in the environment. The allergic reaction is usually a rapid response; however, the sensitivity to certain allergens can be acquired over a period. It was previously called the type one hypersensitivity. It is characterized by an over activation of leucocytes, called the mast cells and the basophils following activation of immunoglobulin E (IgE) (Frigas, Gleich 1986). This activation of the basophiles and mast cells triggers an inflammatory response.

Pathophysiology of the allergic response

The type 1 hypersensitivity reaction is initiated when an allergen is introduced to the atopic individual, ...

Analysis of Temporal Trends in Persistent Organic Pollutants in

Analysis of Temporal Trends in Persistent Organic Pollutants in Air, Water, Food Chain and Humans in United States Introduction Persistent Organic Pollutants (POPs) are synthetic organic chemicals, which are persistent in environment. Its long-range transport leads to global pollution. These materials are lipophilic and they are accumulated in the food chain as they are found in fish and marine mammals (Arnot & Gobas, 2006). These toxic materials are spread in environment through different human activities. They pose adverse effects on air, water, food chain and humans. In United States, over the last two decades there has been a continuous ...

Psoriasis and Inflammatory Bowel Disease are two of the most prevalent types of immune disorders. Being diseases of the immune system, both diseases have similarities and, of course, striking differences. Reviewing both of their pathophysiology, incidences of occurrence and maladaptive responses may help us understand how these two immune disorders manifest their symptoms and affect the human body. Psoriasis is considered as the most prevalent autoimmune disorder, particularly the psoriasis vulgaris type (Krueger and Bowcock, 2005). Additionally, the prevalence of psoriasis considerably varies worldwide (Langley, Krueger, and Griffiths, 2005). In USA, an estimated 2% of the population is ...

Introduction

The pharmaceutical industry has for a long period developed small molecule drugs such as acetylsalicylic acid. However, the period after 1970, has been characterized by a revolution in biotechnology resulting in the development of biologic medicines. One of the major biotechnological advancement has been mapping of the human genome leading to therapies such as stem cell and gene therapy. There has been a great investment in biologics. In 2009, the most five prescribed pharmaceutical products were large molecule products (Rozek, 2013). In United States, over a hundred different biologic agents have been approved for use (Pharmacy Practice News, 2013). According to Amgen ( ...

Abstract

Organ transplantation is an important life-saving procedure for those people, who have some problems in their organs. However, the problem of organ transplant rejection is an important issue in this case. In this problem, patient’s immune system starts rejecting the organ as a foreign body. This problem of rejection of the organ can be acute or become chronic. Several diagnostic procedures have also been developed to reduce the problem of rejection of an organ. Scientists have done a lot of research in this regard. Acute rejection needs immediate care. In order to reduce the problem, specialists will check the area ...

Hepatitis is a condition pertaining to the liver. Its name literally means liver inflammation from the Greek words hêpar (liver) and –itis (inflammation). It is caused by several agents but worldwide, the most common medium for its distribution are viruses. There are five types of viruses namely Hepatitis: A, B, C, D, and E; these viruses are unrelated to each other except that they target the liver and cuase inflammation. Among all five Hepatitis B (HepB) is the most transmitted. HepB is caused by the hepatitis b virus (HBV) which belongs to the family hepadnaviridae which have single stranded ...

The immune system has an immune arsenal that help in the combat of infections including the challenging viral infections (Iannello 2006). Upon infection by a virus, the host invariably reacts by activating its line of defenses. These immune defenses can fall into two main groups: the innate immune system (first line of defense) and adaptive immune response. The innate immune system is non-specific in nature, but the adaptive immune system is acquired following previous infections or vaccinations (Iannello 2006). However, viruses continue to undergo an evolution and have engineered strategies that evade the hosts’ immune antiviral responses. This paper examines ...

Introduction

Bacteria are the very first life forms in the history of our planet. Since the beginning they were exposed to extreme changes of temperature, pressure, pH and nutrients; hence, to survive, they had to adapt themselves. One strategy of survival is to go into suspension or dormancy, by converting themselves into a seed form or spores. When conditions become normal, these spores germinate back to vegetative form. This property is also seen in pathogenic bacteria that infect higher animals such as humans. One such group of bacteria is from the Genus Bacillus.When exposed to stress, these bacteria go into dormancy ...

Abstract

The research paper deals with the problem of Merkel cell carcinoma, chief peculiarities, and the possibility of medical treatment. Disease signs and symptoms are highlighted in the opening and subsequent paragraphs of the paper. The pathophysiology, etiology, manifestations, possible complications, and disease treatment are the focal point of the research paper. The research is based on the opinions of the finest subject-field experts, such as professors, doctors, and scientists. Keywords: Merkel cell carcinoma, medical treatment, disease, complication, cure Merkel cell carcinoma is an aggressive skin cancer usually caused by polyomavirus. Scientists and doctors have not managed to ...

Introduction

Antigen Presentation Antigen presentation plays a pivotal role in the immune system through which pathogenic antigens are processed and coupled along with major histocompatibility complex (MHC), and presented to T cells for their effector response. Macrophages, B cells and dendritic cells are the primary antigen presenting cells (APC’s). Intracellular antigens generated by viruses, or some cytoplasmic bacterial antigens are digested by the host cells and coupled with MHC Class I by Transporter associated with antigen Processing complex (TAP), which transports them to the cell surface and presents to CD8+ cytotoxic T cells (Germain, R 1994). These cells elicit a ...

Management of the Postsurgical CABG Patient

Management of the Postsurgical CABG Patient Coronary artery bypass graft (CABG) surgery is a recommended treatment for coronary heart disease (CHD). In the United Kingdom, around 2.7 million people have been diagnosed with this condition (NHS, 2012). The aim of surgery is to relieve angina and shortness of breath by improving the flow of blood to the heart (Parry et al., 2010). These symptoms cause severe discomfort and distress as well as limit the amount and type of physical activity a patient may engage in. Surgery helps patients attain a higher quality of life referred to as satisfaction with life ...

Introduction

The immunological disorders in an individual can occur due to three different reasons. This includes immunological diseases in an immunocompromised individual, or “autoimmune diseases”, or finally an immunological hypersensitivity that can lead to tissue damage.

Immunodeficiency diseases

Immunodeficiency diseases occur due to malfunctioning of the organs or cells in an individual. They are further classified as primary immunodeficiency (PID) and secondary immunodeficiency (SID).

Primary immunodeficiency disease

They occur when there is a direct defect in the immune system. They are further classified into eight groups depending upon the site of the defect. Combined T and B deficiencies. Severe Combined Immunodeficiency (SCID) is an excellent ...

Differentiation of white blood cells by light microscopy

Most mammals have blood consisting of three types of blood cells, Red blood cells (Erythrocytes), White blood cells (Leukocytes) and Platelets (Thrombocyte). These are collectively termed as hematocyte, which simply means blood cell. These cells constitute to around 40% to 45% of the blood volume. The remaining consist of Plasma, which is referred to the liquid part of blood. The total volume of blood can be determined by centrifugation or flow cytometry. The 45% of blood component (blood cells) is termed as hematocrit. Another important component of blood is hemoglobin, which gives blood its red color. It is ...

1.0 Introduction Hemophilia refers to a sex linked recessive, hereditary lifelong bleeding disorder caused by a deficiency or lack of a vital blood-clotting factor. The disorder is therefore associated with excessive and often spontaneous bleeding of mainly internal organs. While hemophilia A is associated with the partial or lack of factor VIII, hemophilia B is a deficiency of factor IX. Without considering the type and severity, there is 1 reported case in every 5000 male births and 1 severe case in every 10,000 male births. Suffice to say that hemophilia A is referred to as the classical hemophilia because it is ...

Question: what does this tell you about this fragment?

The illustration is a 3D structure of E2F4-DNA-DP2 complex. the green fragment is the transcription factor E2F4 protein and it also equates to one out of the four chains that the complete protein has

The fragment functions as a bride between DP-2 and the sequence of DNA. The fragment has the potential of being involved in the process of transcription like functioning as a regulator factor in the cell cycle.

Can you think of a Reason why this stretch is so homologous?

The Yellow fragment corresponds to the DNA-binding domain which is a high homologous sequence of fragment between the E2F series. this portion determines serves as the functional unit of the molecul and ...

Abstract

The adaptive immune response comprises of antibody reactions and cell-mediated responses that are carried out by diverse lymphocyte cells; B cells, as well as, T cells, respectively. B Cells are the main cells involved in the formation of antibodies that flow in blood plasma and even the lymph fluids, where they bind specially to the alien antigens. Binding of antibody inactivates viruses and microbial toxins by blocking their ability to bind to receptors on host cells. Antibodies, also known as immunoglobulin, are big Y-shaped proteins that are typically comprised of two big heavy chains, as well as, two small ...

Psoriasis is a disease that is part of the broader group of disorders known as papulo-squamous disorders. It is one of the most common dermatological conditions in the world. According to the National Psoriasis Foundation its prevalence is nearly 2.2% of the American population, and 2-3% of the worldwide population. It is clinically characterized by papules that are sharply demarcated from the normal skin and plaques, both covered by scaling skin (Harrison’s, 2008). In the past, the studies on psoriasis focused on the hyper- proliferation of the skin cells; but recently, the focus has changed to study the defects ...

In clinical transplantation, an observed complication is that previous red blood cell (RBC) transfusions may reduce the risk of solid organ transplant rejection but increase the risk of bone marrow transplant (BMT) graft failure (Storb and Weiden, 1981). This statement is seemingly a contradiction. It is difficult to understand how RBC transfusions can both reduce the risk of solid organ transplant rejection and increase the risk of BMT rejection. But this contradiction can be resolved by understanding three considerations. First, the immune system is extremely complex and attempts to control its effects routinely have both positive and negative effects ( ...

Hepatitis E is one of the most common viral infections and is responsible for an acute liver disease. The disease was identified back in the 1980’s but did not receive much of attention perhaps due to the low rates of incidence in developed countries in the West (Hoofnagle, Nelson, & Purcell, 2012; Kumar, Subhadra, Singh, & Panda, 2013). Hepatitis E affects approximately twenty million people every year, most of whom reside in Africa and South East Asia. The virus has attracted significant attention over the past few years due to an increased incidence in countries such as The United States, ...

Human Immunodeficiency Virus, HIV is a retrovirus, which is a unique virus family consisting of RNA as the genetic material instead of DNA. This genetic material is surrounded by an envelope of lipoprotein. HIV differs structurally from other members of the family retrovirus. It is roughly spherical and has a diameter of around 120 nm. Human Immunodeficiency Virus comprises of two copies of non-covalently joined positive single-stranded RNA enveloped by a conical capsid that consist of the p24 viral protein, which is typical of lentiviruses. Lysine tRNA is reverse transcriptase that is magnesium dependent and is involved in the packaging of both ...

Innovative Research Views on Onset and Treatments

Schizophrenia:Innovative Research Views on Onset and Treatments The term “schizophrenia” was coined by Swiss psychiatrist Eugen Bleuler to describe a splitting of psychic functions (Crespi, Sted & Elliot 2010, p. 1736). Schizophrenia is an extremely serious and devastating illness affecting 1% of the American population, causing symptoms that disrupt thought patterns, behavior, and emotions of individuals (Richard & Brahm 2012, p. 757; “Schizophrenia: What” 2012, p. 1). While some sources refer to schizophrenia as a “mental illness,” others refer to it as a “brain disorder” (“Schizophrenia: What” 2012, p. 1; “Schizophrenia” n.d.). Indeed, schizophrenia is a difficult disorder to characterize because its primary symptoms, ...

Introduction

Immunotherapy is a process through which diseases related to or rather affecting the immune system are treated by simply ensuring the capabilities of the immune system are improved.

Such is possible through various ways but the most common method of enhancing the immune system and ensuring its effective is through vaccination. This can also be made possible by eliminating or alternatively controlling some immune responses as evident when dealing with allergy issues. According to Edwin Smith Papyrus, treatment of most complex diseases was effected through surgery as it was considered the most effective method of treatment. This was mostly as ...

Cell Mediated Immunity

Cell mediated is one of the components of the immune response. it involves the expression of cells like natural killer cells, phagocytic cells and antigen-presenting cells. it also involves the release of various forms of cytokines. the varies ways by which cell mediated immunity protect the body includes the activation of macrophages and natural killer cells in order to empower them to destroy antigenic agents like pathogens. it also leads to the formation of substances that modulate the function of cells involved in cell-mediated immunity. In addition, cell-mediated immunity helps in protection of the body by leading to activation ...

Lymphatic System

The lymphatic system is an extensive one way drainage system, which is made up of lymphatic vessels, lymph nodes, the spleen and the thymus. It is part of the circulatory system. The lymphatic vessels have three main functions. Lymphatic vessels drain water and plasma protein that leaks from the capillaries and return them to the circulatory system, they carry fats absorbed in the small intestines to the blood, and transport cellular remains, pathogens, and foreign cells to the lymphoid tissues where white blood cells annihilate them (Starr. C, Targgat, Vers & Starr. L, 2012). Lymph nodes act as sites for ...

Recently United Kingdom research community has proposed several challenges in computer science research with the ambition for development implementation in a wide research area. These Grand challenges would address areas in Non-classical computation which would include the exploitation of the natural world such as DNA and quantum computing in order to develop new areas of computations key being the artificial immune system (AIS). This has been well commented considering the lack of certain issues key being the lack of thought in areas of AIS, theoretical work and the limited view of the immune system. However it has to be agrees ...

Celiac Disease

Introduction This is an autoimmune disease of the gastrointestinal tract. It is also known as celiac sprue, although this name is of less use unlike before. The term sprue simply represent a descriptive term in Dutch and it was used then as a term to describe a disease state characterized by diarrhea, emaciation, apthous stomatitis, and mal-absorption (Cited in Green & Cellier, 2007). Different components has been reported or implicated in the development of the condition. Important predisposing features are the diet, immune response, genetics and environmental factors. The genetic factor contributes in a minor population although there are several people with the ...

CELL TRANSFER DURING PREGNANCY

Many people possess cells that come from people who are genetically different from them (Lee, 2008, p. 72). These cells are mainly transferred from the mother’s body to the fetus. Pregnant women also receive cells from their fetus and harbor them for many years. This was proven by a research that found presence of male cells in bodies of women who had given birth to boys. This cell can stay in the recipient’s body for a long time and sometimes they intermingle with stem cells to form body tissues through a process referred to as microchimerism. In the article the ...

1.0 Background of Immune Tolerance

The immune system is the natural defense that combats disease causing agents in the body[ CITATION Gre02 \l 1033 ] through an intricate and coordinated interactions of many classes of proteins and cells[ CITATION Len00 \l 1033 ].The immune system has a potential to destroy the body cells but in all vertebrates the system is capable of distinguishing “self” from “non-self” molecules. That way the immune system eliminates pathogens and molecules that are a threat to the integrity of the organism without “self-destructing”[ CITATION Len00 \l 1033 ]. The human body has several mechanisms of either suppressing or eliminating autoreactive immune cells. Some ...

Abstract

Stress is a dynamic and interactional process involving intricate body systems with formulations and operationalisation of the components at different levels(1).There is growing evidence that there is a positive correlation between emotional stress and oral health. As will be demonstrated from the literature reviewed in this paper emotional stress can be implicated in oral problems such as ulcerative conditions, inflammatory conditions, dental decay, TMD, RAS and others that continue to be linked to stress. Stress has also been found to aggravate some oral conditions such as oral lichen planus. In some of these conditions the precise mechanisms by which ...

Do people who take vitamins recover faster from the flu and produce a more significant immune response?

Flu, also commonly known as influenza or Grippe, is a virus disease that attacks by infecting the respiratory system, nervous or gastrointestinal system (stomach flu). Rarely fatal, it often opens the door to Pneumonia, Eye and Ear infections and Brian inflammation that do threaten life. Common colds are usually confused with Influenza, in view of both these ailments attacking the upper respiratory system and showing similar symptoms. In fact they are both caused by different viruses. The worst catastrophe was a devastating world-wide epidemic (pandemic) of Influenza stuck during the summer-winter of 1918 taking the total death toll to about 10 ...