Essays on Isomer

Section 1. Renal Excretion of Drugs and their Metabolites

Determine whether your drug is: a) Primarily excreted unchanged (as the parent drug) in the urine (renally cleared) b) Excreted in the urine principally as metabolites (metabolised; hepatically cleared)

Salbutamol is cleared through the urinary system, metabolizing through the inactive 4’-O-sulphate (phenolic sulphate). Within the urine (with a minor extraction method being faeces), both the salbutamol and the metabolite sulphate are excreted. In studies, urinary excretion of salbutamol has resulted in around 64% of a dose being excreted as unchanged salbutamol, with about 12% excreted as the sulphate conjugate (Spina, 2003).

Section 2. Drug Metabolism

For your drug: a) discuss its metabolism noting the ...

Discuss the roles of the Therapeutic Goods Administration (TGA) and the Pharmaceutical Benefits Scheme (PBS) in the provision of drugs. Therapeutic Goods Administration is one of the major Australian Government Department of Health and Ageing branches and it focus mainly on helping the government to regulate various forms of therapeutic goods such as the medicines, medical equipments, implants, vaccines and haematological products. The importance of their role to the community is that those goods are something that people use every day. The goods are used in the management of different major medical conditions (Australian Government, 2011). The ...