Translational medicine involves the application of pharmacology tools, in vivo assays, biomarkers, pre-clinical and clinical methods and studies integrated to improve understanding of various disease states and advancement and approval of therapy against diseases. The development of a new drug is a cumbersome and expensive process. It involves a series of steps. The traditional method of drug development involves understanding the pathophysiology of the disease, followed by identification and validation of a treatable drug target. The next step involves identification of lead molecule or compound or an antibody specific for the target protein. The preclinical toxicology involves in vitro, in vivo assessment and ...
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