Essays on Macrophage

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Function of the target enzyme HSaD within Tuberculosis (TB)

According to Lack et al., (2007, pp 2-7), tuberculosis is one of the major cause of mortality across the world, especially in underdeveloped countries. This huge epidemic makes it very essential to understand the etiopathogenesis of the disease and the organism causing it i.e., Mycobacterium Tuberculosis. The identification and analysis of this bacterium has been accentuated by gene studies and the necessary genetic machinery required by this organism to survive the macrophage milieu. One such gene is responsible for the synthesis of an enzyme called ...

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Abstract

Asthma and allergic reactions result in inflamed and swollen lung airways. Asthma is of two types, atopic and non-atopic. The asthma symptoms include excessive production of mucus, coughing, tightness in chest, wheezing, and difficulty in breathing. The triggers for atopic asthma are allergens and the hyper-responsiveness of IgE immunoglobulin. Genetic factors are involved in non-atopic asthma that relies on the propensity of developing asthma and hypersensitivity of airways. Epithelial cytokines, macrophage, eosinophils, and T cells collectively influence the fibroblast production resulting in muscle mutagenesis and bronchial ...

The binding of antibodies to red blood cells can lead to potentially fatal outcomes such as hemolytic transfusion reactions, autoimmune hemolytic anemia, and hemolytic disease of the fetus/newborn.1 Information regarding the first steps of hemolytic transfusion reactions is well documented. It is, however, unclear why the severity of hemolytic transfusions experienced by different individuals ranges from mild to very severe.2 The pathophysiology of the final pathways and downstream events of red blood cell hemolysis are also yet to be fully elucidated although research is ongoing.2 A recent study by Liepkalns et al. (2012)1 has reinvigorated debate on the ...

Research Plan

Introduction Toxin-antitoxin (TA) systems incorporate pervasively in prokaryotic genomes that have also been suggested to perform a role in numerous critical cellular operations (Van, & Bast, 2009). These systems characteristically comprise of a two-gene operon encoding a toxic protein molecule which aims at an important cellular purpose and an antitoxin that connects to and hinders the toxin. Control of toxin action is attained via differential constancy of the stable toxin as well as the unstable antitoxin (Kamada & Hanaoka, 2005). In several occasions, the antitoxin also operates as a transcriptional autorepressor of the operon, whereby the degradation of the antitoxin leads to transcriptional introduction ...

Introduction

Legionnaires’ disease was first recognized in 1976 following its breakout in a hotel in Philadelphia housing delegates who had attended American Legion convention (Lynch, Brightman, & Greenberg, 1994). Its causative agent is a bacterium known as Legionella pneumophila (Lynch, Brightman, & Greenberg, 1994). This disease presents with symptoms similar to those associated with pneumonia. Legionella pneumophila also cause another disease known as Pontiac fever (PF). Pontiac fever and Legionnaires’ disease are collectively referred to as legionellosis. According to Centers for Disease Control and Prevention (2011), crude national incidence rate of legionellosis in the United States increased by 192% from 2000 to 2009.

Etiology/Pathology

Legionella ...

Tuberculosis is one of the oldest diseases known to cause medical illness in humans, and is the second most common cause of death due to infection worldwide (Riley, 2013). The bacteria mycobacterium tuberculosis (M. Tuberculosis) causes the disease; and while it is widely known that it affects the lungs of the individual, other organ systems may be affected in nearly one-third of cases (Harrison’s, 2008). Proper treatment in drug-susceptible strains leads to a cure; however, drug resistant strains or improper treatment has a 5-year survival rate between 50-65% of cases (Harrison’s, 2008). Transmission is through respiratory droplets passed from ...

Human Immunodeficiency Virus, HIV is a retrovirus, which is a unique virus family consisting of RNA as the genetic material instead of DNA. This genetic material is surrounded by an envelope of lipoprotein. HIV differs structurally from other members of the family retrovirus. It is roughly spherical and has a diameter of around 120 nm. Human Immunodeficiency Virus comprises of two copies of non-covalently joined positive single-stranded RNA enveloped by a conical capsid that consist of the p24 viral protein, which is typical of lentiviruses. Lysine tRNA is reverse transcriptase that is magnesium dependent and is involved in the packaging of both ...

According to Typep-1 Siegenthaler & Aeschlimann, (2007) the neme diabetes wass derived from a greek word, diabeinein which implies “to siphon”. There are two main types id diabetes (type 1, type 2) even though some researchers often contend that there is a third type called gestational diabetes. Ideally,type 1 diabetes is autoimmune conditions that occurs when the beta cells of the pancreas have been spifflicated (Siegenthaler & Aeschlimann, 2007; News medical, 2013). The leads to loss of glucose that becomes visible in the urine if it is above the renal threshold that is 190 to 200 mg/dl on average. This condition of ...

Mycobacterium Tuberculosis

Introduction Mycobacterium tuberculosis is a species of bacteria that is pathogenic( Herchline, 2012). It is one of the members of the Mycobacterium genus. It was first discovered by Robert Koch in 1882. It is described as being an acid-fast organism because it has a waxy coat composed of mycotic acid. This coat, which does not allow gram, stains to take. Mycobacterium tuberculosis is an aerobic organism that requires high level of oxygen to survive. Mycobacterium Tuberculosis is an acid-fast bacterium that forms stable complexes with aryl methane dyes. Mycobacterium has peptidoglycan structures, which confers on them the acid-fast properties ...

Monkeys from HIV-Like Infection

Microbiology: Journal Review

“Experimental Vaccine Partially Protects Monkeys from HIV-Like Infection” www.ScienceDaily.com

Many websites are available for serious researchers to access and share information. Unfortunately the mass media for the most part does not offer journalists with expertise in science. People are interested in the health of their families and need to know about medical research. The www.ScienceDaily.com is a website that offers the most recent research and scientific news in non-scientific language. This paper reviews an article from the ScienceDaily.com website. Three scientific research websites are evaluated.

Too many people are being infected by the Human Immunodeficiency Virus ( ...