!Marfan syndrome is an autosomal dominant disorder of connective tissue and mainly caused due to heterozygous mutations in fibrillin-1 encoding gene. This syndrome was described by Antoine Bernard-Jean Marfan in the year 1896. This disorder involves skeletal, ocular, cardiovascular systems, dura, lungs and integument. The manifestations observed are aortic aneurysm, dislocation of ocular lens, over growth of long bone. Most of the cases are due to FBN1 mutations. This syndrome affects 1 in 3000-5000 and one-fourth of the cases are sporadic. Diagnosis of this syndrome is often challenging since it is age-dependent and frequent in all types of populations, ...
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