Essays on Medicinal Chemistry

Hansch Analysis

Hansch analysis is used widely in the field of medicinal chemistry. It is the analysis that investigates the quantitative relationship and correlation between the compound’s biological activities with their physicochemical substituents. The global parameters considered in this method include the electronic, steric, hydrophobic, and other effects that use multiple correlation methodology (IUPAC). Application of the Hansch analysis includes the Quantitative Structure-Activity Relationship (QSAR). This application develops correlations between activity of the ligands and their properties. As a rule of the thumb, the Hansch model “gives information about the number of parameters to be selected for regression analysis in ...

Abstract

Cocaine has a variety of physiological manifestations. Cocaine is a local anesthetic that was discovered in the sixteenth century. The characteristic of being a local anesthetic is the primary attribute for its application in medicine. There are a number of compounds that have been recently created that are more effective than cocaine for the purposes of anesthesia. Cocaine also has the characteristic of being a potent vascoconstrictant. The applications of vascoconstrictant are effective for the implementation of throat and nose surgery. The application of cocaine in the nose and throat areas has the characteristic of deterring bleeding. Cocaine also has influence over the sympathetic ...