Essays on Mefloquine

Abstract

Plasmodium falciparum is the parasite responsible for the deadly disease, malaria. The parasite is transmitted through the injection of sporozoites into the human blood stream. These sporozoites are transported in the blood stream to the liver. The sporozoites invade the hepatocytes and differentiate into merozoites. The merozoites invade the RBCs of the host; starting the blood stage of infection. The trophozoite stage ingests and degrades approximately 80% of the hemoglobin in the host cell. The hemoglobin is broken down into peptides due to enzymatic action by a metalloprotease and cysteine and aspartic proteases. Haematin is first released as a byproduct of ...

Describe the Hemoglobin Digestive Process

P. falciparum, is the parasite responsible for the malaria, a disease that causes approximately one million deaths annually. It undergoes the process of erythrocytic schizogony which is responsible for the clinical manifestations of malaria. The trophozoite ingests and degrades approximately 80% of the hemoglobin in the host cell (Brayl 2005). As the trophozoite continues to develop, its endolysosomal system takes up the cytoplasm of the host cell using cytosomes which contains host hemoglobin. Cytosomes are formed by an invagination formed from the PVM (parasitophorous vacuolar membrane) and PPM (parasite plasma membrane) from which transport vesicles are pinched off. These vesicles ...