MicroRNAs are small, single-stranded, non-coding, 16–29 nucleotide RNA molecules comprising of an evolutionarily conserved class of endogenous ribo-regulators that regulate gene expression (Wiemer, 2007; Garzon et al., 2009). They were discovered in 1993 in the nematode Caenorhabditis elegans (Espinosa & Slack, 2006). Currently, 4167miRNAs are listed in the miRNA registry and 474 human miRNAs have been identified (Wiemer, 2007). MicroRNAs are crucial for the development of vertebrates due to the fact that depletion of the components of the miRNA processing pathway, or interfering with maturation of miRNAs, is not compatible with life (Wiemer, 2007). The miRNA ...
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