1.0 Introduction Cannabinoids are a group of terpenophenolic compounds present in Cannabis sativa (commonly known as marijuana) and are structurally related to tetrahydrocannabinol (THC). The discovery of Endocannabinoids (endogenous cannabinoids), which occur naturally in the nervous system, where they bind to cannabinoid receptors (CB1) and also in the immune cells receptors CB2 led to speculations that plant and synthetic Cannabinoids could be useful therapeutically and particularly in neuropharmacology. Therefore there have been efforts to understand the roles and mechanism of action of endocannabinoids in modulating the neuronal function and the development of synthetic cannabinoids for clinical use. Synthetic THC ...
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