Essays on Nucleoside

INTRODUCTION

In the 1980s a new disease was spreading. It was previously unknown, but seemed quite contagious and quite virulent. HIV, the Human Immunodeficiency Virus, is defined exactly as it sounds. It is a virus that causes an infection that negatively affects the immune system. That infection attacks and weakens the immune system, making an individual at greater risk for contracting other opportunistic diseases. When the immune system becomes too damaged it leaves the patient open to contracting AIDS, the Acquired Immunodeficiency Syndrome, which essentially disables the immune system, which leaves sufferers to deal with many of unpleasant symptoms associated ...

HIV/AIDS

December 1, is World’s AIDS Day. At the initiative of the World Health Organization, for the first time, this date was marked as World AIDS Day on December 1, 1988. At that time, around 7 million people were infected with HIV. In 5 years there were already 14 million, today more than 36.9 million people in the world are living with HIV (“Global Statistics”). The first notice of new disease was placed in 1981 in the American weekly newspaper “Morbidity and Mortality Weekly Report”. According to some scientists the human immunodeficiency virus derived from green monkeys immunodeficiency virus. ...

1. The molecule chosen for the analysis is Immunicillin -H. It is a transition state analogue for the enzyme purine nucleoside phosphorylase (PNP). Chemically Immunicillin -H is [(1S)-1-(9-deazahypozanthine-9yl)-1,4-dideoxy-1,4-imino-D-ribitol] (Kicska et al. 2001) 2. PNP is important for the degradation of nucleotides, especially deoxy guanosine. In the absence of this enzyme, deoxy guanosine accumulates and inhibits T cell function, causing T cell mediated immunosuppression. Inhibitors of PNP were found useful in treating T cell malignancies. Inhibiting PNP using transition state analogue, triggers apoptosis of T cells. Though Immunicillin-H inhibits stimulated malignant and nonmalignant T cells, ...

Acquired immunodeficiency syndrome (AIDS) is a condition caused by a progressed state of infection by the human immunodeficiency virus (HIV). The retrovirus can be transmitted through bodily fluids such as blood, semen, breast milk, and vaginal fluids via the bloodstream or mucous membranes (Moss; Maartens et al.; Simon et al.). Infection by HIV typically has four stages. The first stage is acute or primary infection which may last up to a few weeks, during which the infected person may either be asymptomatic or have flu-like symptoms such as fever, rash, malaise, body aches, chills, and swollen lymph nodes. Progression of the ...

- If K65R and D113E are conserved mutations, what type of mutations are Q151M and Q151N. They are non-conserved is not the correct answer. K65R and D113E being conserved mutations implies that even after undergoing mutations they retain the original properties. There functionality remains almost the same. On the other hand, Q151M and Q151N, mutations will result in a change of their initial properties or additional functions may be gained in the process of mutation. - The K65A RT mutant had a reduction in RT activity. Explain the reasoning behind this phenotype In the cell, the presence of ...

Introduction

Herpes Simplex virus type 2 (HSV-2) is a virus that belongs to the alpha herpes viridae subfamily and causes genital ulcer diseases. The transmission of HSV-2 occurs most often due to a sexual intercourse in humans, although it can disseminate through physical contact with the lesions and saliva from the patients. Medical professionals may contract the infection and lesions on their fingers, if they inadvertently contact the patient’s vaginal mucosa or mouth, without using appropriate gloves. The HSV-2 infection is known to be asymptomatic in 80 % of the cases . Genital herpes is a frequent infection acquired during pregnancy and about 5 % ...

- The answer to this question depends on the definition of an STD. For instance, Shigella was once though to be a Gastrointestinal disease, but with modern sexual practices and the increase of oral to anal intercourse it is now becoming an STD as well. Therefore, no precise number of STDs can be stated but there are now >30 infections classified as predominantly sexually transmitted (Harrisons, 2008, p. 822) - The most common viral STD is HPV. It is said that nearly ½ of the population is infected with the virus at any given time. Both males and females can ...

Chemistry

Trizivir: Ingredients: 3 synthetic nucleoside analogues with inhibitory activity against HIV-1. “A recently approved antiretroviral looks like a nucleoside reverse transcriptase inhibitor (NRTI), but it acts like a protease inhibitor” (Portyansky 1999).

Active Ingredients:

1. abacavir sulfate, 300 mg (aka Ziagen™) 2. lamivudine, 150 mg (aka EIVIR™ or 3TC™) 3. zidovudine, 300 mg (aka RETROVIR™ or azidothymidine, ZDV or AZT because of Azide functional group).

Additives:

1. titanium dioxide 2. hypromellose 3. yellow iron oxide

Coating on Tablets

Is FD&C Blue No. 2, hypromellose, polyethylene glycol, titanium dioxide and yellow iron oxide

Inactive Ingredients: 1. sodium starch glycolate ...