Describe the underlying pathology of COPD and the common pathological characteristics of the condition. Discuss the impact these pathological changes have on normal function, including how alveolar ventilation might be different in Mr Wenham compared to a normal individual. The hallmark pathological attributes of chronic obstructive pulmonary disease (COPD) are one, poorly reversible airflow obstruction and two, a progressive atypical inflammatory response within the lungs. The abnormal inflammatory response denotes the responses of the innate and adaptive immune systems to long-standing exposure to noxious gases and particles especially cigarette smoke. Notably, all cigarette smokers have some degree of inflammation ...
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As incremental exercise progresses, the lower lobe of the lung exhibits an increase in alveolar PO2, a decrease in alveolar PCO2, and a marked increase in mixed venous PCO2. During exercise, the ventilation rates increase gradually from resting values of around 5-6 liters per minute to over 100 liters per minute. On average, the rate of oxygen consumption is 250ml per minute but as during high intensity exercise, this can go up to 5000ml per minute. Increased pulmonary ventilation triggers a subsequent rise in the tidal volume of the lungs and respiratory rate hence more oxygen is taken into the alveoli. The ...
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