Essays on Pharmacoepidemiology

Ray WA, Chung CP, Murray KT, Hall K, Stein C. Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain. JAMA. 2016;315(22):2415-2423. doi:10.1001/jama.2016.7789.

Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain Wayne A. Ray, PhD1; Cecilia P. Chung, MD, MPH2; Katherine T. Murray, MD2,3; Kathi Hall, BS1; C. Michael Stein, MB, ChB2,3 [+] Author Affiliations JAMA. 2016;315(22):2415-2423. doi:10.1001/jama.2016.7789.

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Abstract ABSTRACT | INTRODUCTION | METHODS | RESULTS | DISCUSSION | CONCLUSIONS | ARTICLE INFORMATION | REFERENCES Importance  Long-acting opioids increase the risk of unintentional overdose deaths but also may increase ...

DRUG EVALUATION IN CLINICAL PRACTICE

FDA has established the Centers for Drug Evaluation and Research (CDER) to evaluate new drugs before they can be sold. The aim of drug evaluation is to prevent quackery and to provide the necessary information to the doctors and patients so that they can use the drugs wisely. Drug evaluation process ensures that both branded and generic drugs work correctly and their benefits outweigh their risks. The pharmaceutical companies test their drugs to prove their safety and effectiveness for the intended use. The results of these tests are then shared with the CRERs where clinicians, statisticians, chemists, pharmacologists and ...