Essays on Phosphorylation

The team of specialists provided a research on the role of Gleevec in the treatment of insulin resistance and type 2 diabetes. This study was published in the journal Diabetes in 2016 and presents a new intervention for the treatment of type 2 diabetes in adults and children. The main problem is that obesity is widespread nowadays, it results in diabetes, dyslipidemia, hypertension, and cardiovascular diseases. The key idea is that Gleevec can be a novel therapeutic agent for use in insulin resistance and type 2 diabetes only if its potential adverse effects will be removed (Choi 2016). However, ...

According to Squire (2009), the altered respiratory pattern in AMPK KO neonatal mice has attracted a lot of scientific approaches to reach out to traditional answers. Knockout mice and transgenic models have however come up with relativity pyramids, which have been efficient enough in explaining why AMPK KO neonatal exhibit altered respiratory patterns(Bertoldo, et al., 2009). This paper bases its assertions on relevant literature to depict the how AMPK, out of its function as a fuel gauge, plays a critical role in the control of respiratory patterns in neonatal mice. AMPK protein kinase is a proposed energy regulator. ...

Vid30 complex participation in the degradation of CDC25 in yeast and their role in Ras/ cAMP/ PKA pathway

Background: Unicellular organisms such as Saccharomyces cerevisiae in its total life cycle is exposed to diverse and changing nutrient conditions. Thus, in order to survive and achieve a competitive advantage, it has adapted itself such that it not only uses the wide range of available nutrient sources but also the sources that are nutrient rich. It mainly uses fructose and glucose by rapidly fermenting to alcohol. In response to these nutrient conditions, the intracellular trafficking transcription and turnover of protein from nutrient transporters (e.g. Hxts) get regulated. Therefore, when the availability of the glucose increases, the expression of low- ...

The activity of AMPK supports the normal function of the endothelial barrier (Xing, Wang, Coughlan, Viollet, Moriasi, & Zou, 2013), while on the other hand, the exposure of LPS ensures that there is inhibition of AMPK, thus accentuating lung injury and endothelial barrier dysfunction (Kratzer et al., 2012). It is a fact that LPS increases the permeability of the endothelium, which occurs once there is a decrease in the AMPK activity. This is consistent with the fact that the activation of AMPK activator, AICAR, emphasizes LP, once it is applied in vitro to test the hyper endothelial permeability. Experiments done ...

Cellular respiration equation:

C6H12O6+6O2→6CO2+6H2O+38ATP. Glucose+Oxygen→Carbon dioxide+Water+38ATP.

Photosynthesis equation:

6CO2+6H2O+sunlight, nutrients→C6H12O6+6O2. Carbon dioxide+Water→Glucose+Oxygen. Respiration and photosynthesis are opposite processes. It means that products of cellular respiration are reactants of photosynthesis and vice versa: the products of photosynthesis are reactants for cellular respiration. It is known that plants are autotrophs. Thus, they have to realize cellular respiration because they need energy for their existence. Due to cellular respiration, they receive energy, which is used to make organic compounds (glucose) and oxygen during photosynthesis. From the other side, people are heterotrophs. They ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...

The title of the paper that is reviewed is: “Sumoylation and Phosphorylation of α-synuclein”.

It is a research article that explores the molecular mechanism underlying αSyn toxicity. αSyn is a protein that is seen in the inclusion bodies of dopaminergic neurons in patients with Parkinson’s disease. Parkinson is an important neurodegenerative disease, and the cure of the disease is still unknown. In-depth understanding of the molecular pathogenic of the disease will help in determining suitable cure. Through the insight obtained from a literature review and previous studies, the authors identified that post translational modification of αSyn, could affect its physical characters like the ability to form aggregates, solubility in cytoplasm and its ...