Essays on Prohormone

Rat Endocrinology

Hypothalamus 1. What is the molecular mechanism to release TRH? TRH refers to the thyrotropin-releasing hormone. This hormone is produced by the hypothalamus. Before the full activity of TRH, some tightly controlled processes occur in the body including the appropriate folding of prohormone to move to the secretary pathway, the processing after translation, and movement of the peptides, which are processed, towards the secretary granules for secretion (Nillni n.p.). TRH develops from bigger inactive precursor (known as proTRH) as a result of modifications after translation and moved through the controlled secretary pathway. Prohormone convertases (abbreviated as PCs) including PC1/3 ...

Abstract

Obesity is a heritable and genetically influenced disorder. Recent studies have proved that obesity is a biochemically driven neurological disorder. Obesity has a complex and heterogeneous genetic and phenotypic manifestation. Familial obesity is monogenic and common obesity is polygenic. Leptin and its receptor (LEPR), the α-melanocortin-stimulating hormone receptor (MC4R), pro-opiomelanocortin (POMC) and prohormone subtilisin/kexin type 1 (PCSK1) are some of the single genes involved in monogenic obesity. Glutamate Decarboxylase 2 gene (GAD2) gene is thought to be part of a polygene system resulting in common obesity. GAD2 coding sequence is present on chromosome 10p locus and encodes for a protein GAD65. This protein catalyzes ...