Essays on Protease

Transcriptional regulation of gene expression

Gene expression in eukaryotic cells is regulated at transcriptional, post transcriptional and translational levels (Tomizawa,  Lekstrom-Himes, and Xanthopoulos 17). Transcriptional control is the primary means of regulating gene expression. Eukaryotic transcriptional control functions at three levels: modulation of the activities of activators and repressors; variations in chromatin structure; and effect of activators and repressors on assembly of initiation complexes (Lodish et al. 368). Regulation of transcription initiation is the most widespread form of gene control in eukaryotes. However, in some cases, transcription may be attenuated and regulated at subsequent steps, such as during or after the transcription process (Cooper ...

Describe the underlying pathology of COPD and the common pathological characteristics of the condition. Discuss the impact these pathological changes have on normal function, including how alveolar ventilation might be different in Mr Wenham compared to a normal individual. The hallmark pathological attributes of chronic obstructive pulmonary disease (COPD) are one, poorly reversible airflow obstruction and two, a progressive atypical inflammatory response within the lungs. The abnormal inflammatory response denotes the responses of the innate and adaptive immune systems to long-standing exposure to noxious gases and particles especially cigarette smoke. Notably, all cigarette smokers have some degree of inflammation ...

Since the introduction of Antiretroviral Therapy (ART), the health prospect for the HIV-infected population has evolved considerably. The application of ART has led to a significant reduction in the rate of mortality for this group of people (Chastain et al., 2015). However, the number of deaths resulting from non-HIV-related diseases including cardiovascular diseases (CVD), hepatic disease, and cancer has taken the opposite turn. This paper evaluates the association between CVD and the administration of ART among HIV patients. A study in this area may be helpful in reducing the occurrence of CVD in the HIV-infected population. A prompt detection ...

HIV/AIDS

December 1, is World’s AIDS Day. At the initiative of the World Health Organization, for the first time, this date was marked as World AIDS Day on December 1, 1988. At that time, around 7 million people were infected with HIV. In 5 years there were already 14 million, today more than 36.9 million people in the world are living with HIV (“Global Statistics”). The first notice of new disease was placed in 1981 in the American weekly newspaper “Morbidity and Mortality Weekly Report”. According to some scientists the human immunodeficiency virus derived from green monkeys immunodeficiency virus. ...