Glade Bender JL, Lee A, Reid JM, Baruchel S, Roberts T, Voss SD, Wu B, Ahern CH, Ingle AM, Harris P, Weigel BJ, Blaney SM. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report. J Clin Oncol. 2013 Aug 20;31(24):3034-43.
This study describes a phase I clinical trial of “Pazopanib” in pediatric patients suffering from soft tissue sarcoma (STS). Pazonapib is an anti-angiogenic drug. It is a competitive inhibitor of ATP molecule1,2. It competes with the ‘substrate’ ...
